BACKGROUND It is widely recognized that only a handful of drugs are available against soil-transmitted helminthiasis, all of which are characterized by a low efficacy against Trichuris trichiura, when administered as single doses. The re-evaluation of old, forgotten drugs is a promising strategy to identify alternative anthelminthic drug candidates or drug combinations. METHODOLOGY We studied...

Porphyromonas gingivalis is a major pathogen of chronic periodontitis and exists in a biofilm on the surface of the tooth root. Oxantel, a cholinergic anthelmintic and fumarate reductase inhibitor, significantly inhibited biofilm formation by P. gingivalis and disrupted established biofilms at concentrations below its MIC against planktonic cells. Oxantel was more effective against P. gingivali...

Pyrantel has been demonstrated (Bumbalo et al., 1969; Desowitz et al., 1970; Hsieh, 1971) to be effective for treatment of Ascaris, hookworm and Enterobuis. Oxantel has been shown (Zaman and Sabapaty, 1975; Garcia, 1976; Lee et al., 1976; Rim et al., 1976) to be effective against Trichuriasis. A combined Oxantel-pyrantel salts has been shown (Rim et al., 1975; Lim, 1978; Dissanaike, 1978; Cabre...

BACKGROUND Infections with soil-transmitted helminths (Ascaris lumbricoides, hookworm, and Trichuris trichiura) are widespread and often occur concomitantly. These parasitic-worm infections are typically treated with albendazole or mebendazole, but both drugs show low efficacy against T. trichiura. Albendazole is the drug of choice against hookworm. METHODS In this double-blind trial conducte...

Millions of people are treated with anthelmintics to control soil-transmitted helminth infections; yet, drug distribution in the plasma and gastrointestinal tract compartments and the pathway of drug uptake into gastrointestinal nematodes responsible for the pharmacological effect are unknown. We assessed the distribution and uptake of albendazole, albendazole sulfoxide, albendazole sulfone in ...

the effect of a combination of oxantel- pyrantel with a single dose of 10 mg/ kg body weight on trichuris trichiura, ascaris, trichostrongylus spp. and ancylostoma duodenale has been evaluated among the population of two rural areas in khuzestan, southwest iran (41 persons) and isfahan, central (30 persons). all patients were infected with trichuris trichiura and some simultaneously with one or...

n engl j med 370;20 nejm.org may 15, 2014 1954 transmitted helminth infections: systematic review and metaanalysis. JAMA 2008;299:1937-48. 3. Keiser J, Tritten L, Silbereisen A, Speich B, Adelfio R, Vargas M. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. PLoS Negl Trop Dis 2013;7(3):e2119. 4. Nagpal S, Sinclai...