osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (sns) and bone metabolism. leptin has been shown to regulate bone formation and bone resorption via the sns. however, the effect of sns on leptin signaling has not been clearly understood. in the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

objective: melanocortin-4 receptor (mc4r) and agouti-related peptide (agrp) are involved in energy homeostasis in the rat. the aim of the present study was to evaluate the expression of mc4r and agrp mrnas in arcuate nucleus (arc) during long term malnutrition of female ovariectomized rats. materials and methods: ten female ovariectomized rats were divided into two equal groups (n=6) of normal ...

Background: Osteoporosis is one of the uncomfortable postmenopausal symptoms. The risk of imbalanced nutrition especially traces elements and vitamins are high during post menopause and may lead to osteoporosis due to reduction of content of mineral bone. The aim of this study was to investigate the potential consequence of Selenium (Se) treatment in ovariectomized rat model with osteoporosis i...

Background and Aim: Cessation of ovarian function is a major cause postmenopausal osteoporosis. Ovariectomized rats dogs have been used extensively in osteoporosis models. This study examined the effect Pueraria Radix isoflavone extract not only on Bone Mineral Density (BMD) but also bone strength using formation resorption markers ovariectomized as an model. Methods: The model (OVX) induced by...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

Osteoporosis is a systemic skeletal disease and there is a close relationship between the sympathetic nervous system (SNS) and bone metabolism. Leptin has been shown to regulate bone formation and bone resorption via the SNS. However, the effect of SNS on leptin signaling has not been clearly understood. In the present study, we studied the effect of propranolol on ovariectomy-induced osteoporo...

Purpose: To investigate the effect of puerarin on symptoms depression in ovariectomized female rat model, and mechanism action involved.
 Methods: Ninety healthy Sprague Dawley (SD) rats were assigned to five groups: sham, low-dose puerarin, medium-dose high-dose groups, with 18 per group. Changes levels dopamine (DA), norepinephrine (NA), 5-hydroxytryptamine (5-HT), apoptosis-related prot...

background: melatonin has receptors in substantia nigra pars compacta (snc) and regulates development of dopaminergic (da) neurons. this study was undertaken to determine ability of melatonin to protect snc dopaminergic neuron loss induced by estrogen deficiency in ovariectomized rats. methods: female rats were randomized into four groups of seven each: control, ethanol sham, ovariectomy (ovx) ...

Makaverich et al. [Environ Health Perspect 103:574-581 (1995)] reported that the uterotrophic activity of the phytoestrogen coumestrol in the immature ovariectomized rat was atypical in that it was not associated with increased uterine hyperplasia and DNA content. We previously reported that coumestrol gave a typical estradiol-type uterotrophic response in the immature intact rat, yielding incr...

Objective: The aim of this study was to investigate the possible effect of sex steroid deficiency on the rat tongue mucosa as well as the effect of its replacement. Methods: We chose 21 sexually virgin female Wistar albino rats in this study. We divided the model rats into 3 groups: Group-1:Control, Group-2: Sham-operated (bilaterally ovariectomized), and Group-3: Sham-operated, in addition we ...