Several studies have focused on polymorphisms of major histocompatibility complex (MHC) in sheep, Ovar-MHC. This molecule plays a pivotal role in antigen presentation for eliciting immune responses against invading pathogens. The best-characterized genetic control of disease resistance and immune response in animals is associated with MHC. Numerous molecular genetic investigations have been und...

The major histocompatibility complex (MHC) plays a central role in the control of disease resistance and immune response. Extensive genetic diversity in MHC genes provides a valuable source for genetic improvement, via selection, in many domestic animals. Exon 2 of the class II MHC, termed Ovar-DRB1 in domestic sheep (Ovis aries), has been suggested as important disease resistance and immune re...

This study was designed to identify genetically resistant animals to gastrointestinal nematode (GIN) infections using microsatellite polymorphisms of Ovar-DRB1 gene in Iranian Ghezel sheep breed lambs. In the present study 120 male Ghezel lambs were at 4 to 6 months of age randomly selected from six different sheep flocks in East Azerbaijan province (n=20 per flock). These lambs were naturally ...

several studies have focused on polymorphisms of major histocompatibility complex (mhc) in sheep, ovar-mhc. this molecule plays a pivotal role in antigen presentation for eliciting immune responses against invading pathogens. the best-characterized genetic control of disease resistance and immune response in animals is associated with mhc. numerous molecular genetic investigations have been und...

Genetic improvement programs may improve disease resistance in animal production. The best-characterized genetic control of disease resistance and immune response in animals is the one associated with the Major Histocompatibility Complex (MHC). The ovine lymphocyte antigenof DRB1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

genetic improvement programs may improve disease resistance in animal production. the best-characterized genetic control of disease resistance and immune response in animals is the one associated with the major histocompatibility complex (mhc). the ovine lymphocyte antigenof drb1 gene encodes cell surface glycoproteins that initiate immune responses by presenting processed antigenic peptides to...

Highly polymorphic genes with central roles in lymphocyte mediated immune surveillance are grouped together in the major histocompatibility complex (MHC) in higher vertebrates. Generally, across vertebrate species the class II MHC DRA gene is highly conserved with only limited allelic variation. Here however, we provide evidence of trans-species polymorphism at the DRA locus in domestic sheep (...

the major histocompatibility complex (mhc) plays a central role in the control of disease resistance and immune response. extensive genetic diversity in mhc genes provides a valuable source for genetic improvement, via selection, in many domestic animals. exon 2 of the class ii mhc, termed ovar-drb1 in domestic sheep (ovis aries), has been suggested as important disease resistance and immune re...