Chronic obstructive pulmonary disease (COPD) is considered an inflammatory pulmonary disorder with systemic inflammatory manifestations. The aim of this study was to assess the systemic levels of six inflammatory mediators in a large cohort of COPD patients and controls. 409 COPD patients and 231 healthy subjects, aged 40-75 yrs, were included from the first phase of the Bergen COPD Cohort Stud...

relationship of salivary rankl and opg with periodontal disease in type 1 diabetic patients      dr. ghasemi m .,1 dr. sattari m., 2 dr. khamseh me., 3 dr. kavoli s. 4    1 associate professor, department of periodontics , school of dentistry, islamic azad university. tehran, iran .   2 associate professor, department of immunology , school of medicine, shahid beheshti university of medical sci...

The present study aimed to determine the mechanism by which low‑intensity intermittent negative pressure affects the differentiation and proliferation of human mesenchymal stem cells (MSCs). Alkaline phosphatase (ALP) activity, type I collagen and vascular endothelial growth factor (VEGF) were detected to analyze differentiation. MTT and flow cytometry were employed to measure proliferation and...

RANKL: Receptor activator of nuclear factorkappa B ligand; PTHrP: Parathyroid Hormone Related Peptide; ACTH: Adrenocorticotropic Hormone; POMC: Pro-Opiomelanocortin; PNES: Paraneoplastic Endocrine Syndrome; OPG: Osteoprotegrin; CS: Cushing’s Syndrome; CLIP: Corticotrophin-Like Intermediate Lobe Peptide; MSH: α-Melanocyte Stimulating Hormone; CLIP: Corticotrophin-Like Intermediate Lobe Peptide; ...

Cerebral malaria is a medical emergency. All patients with Plasmodium falciparum malaria with neurologic manifestations of any degree should be urgently treated as cases of cerebral malaria. Pathogenesis of cerebral malaria is due to damaged vascular endothelium by parasite sequestration, inflammatory cytokine production and vascular leakage, which result in brain hypoxia, as indicated by incre...

background: to evaluate vdr gene variation and its interaction with immune regulatory molecules in osteoporosis. methods: totally 205 pre and postmenopausal women were recruited in the study. after an overnight fast, peripheral blood was taken and centrifuged to sprat serum for measurement of serum parathyroid hormone, 25 hydroxyvitamin d, osteocal­cin and cross laps. the fok i polymorphism in ...