The repair of infected bone defects is still challenging in the fields of orthopedics, oral implantology and maxillofacial surgery. In these cases, the self-healing capacity of bone tissue can be significantly compromised by the large size of bone defects and the potential/active bacterial activity. Infected bone defects are conventionally treated by a systemic/local administration of antibioti...

Integrin-mediated cell-matrix interactions play an important role in osteogenesis. Here, we constructed a novel osteoinductive fibronectin matrix protein (oFN) for bone tissue engineering, designed to combine the integrin-binding modules from fibronectin (iFN) and a strong osteoinductive growth factor, bone morphogenetic protein-2. Compared with iFN, the purified oFN matrix protein caused a sig...

The construction of functional biomimetic scaffolds that recapitulate the topographical and biochemical features of bone tissue extracellular matrix is now of topical interest in bone tissue engineering. In this study, a novel surface-functionalized electrospun polycaprolactone (PCL) nanofiber scaffold with highly ordered structure was developed to simulate the critical features of native bone ...

Although bone grafting has a well-recognised role in orthopaedic surgery for the treatment of nonunion, bridging diaphyseal defects and filling metaphyseal defects, it is associated with postoperative pain and morbidity. When extensive grafting is required, as in spinal arthrodesis and the management of large bony defects, inadequate amounts of autologous bone may not be available. Allograft bo...

Calcium phosphates (CaPs) are extensively used as biomaterials for bone repair and regeneration considered an interesting synthetic alternative natural grafts. However, the regenerative potential of many CaP graft substitutes requires further improvements. The bioactivity CaPs is regulated by a variety properties, including their chemical composition (surface) structural properties. In this stu...

INTRODUCTION: Synthetic calcium phosphate cements (CPC) which mimic the chemical structure of the mineral composition of bone have been well accepted as bone grafting materials due to their consistent osteoconductivity, ease of use, and mechanical properties but are limited in application due to their lack of osteoinductive potential. Demineralized Bone Matrix (DBM) has also found significant a...