search between a Dutch group and a group in Chengdu, China,4,5 revealed that similar bone formation was seen with porous ceramics of various types of hydroxyapatite, tricalcium phosphate, and Bioglass® (NovaBone Products, Alachua, FL, USA). Fujibayashi and others in our department6 also reported that porous titanium processed with alkali-heat treatment has osteoinduction. This material contains...

We developed a novel bone grafting material that incorporates autogenous teeth (AutoBT), and provided the basis for its clinical application. AutoBT contains organic and inorganic mineral components and is prepared from autogenous grafting material, thus eliminating the risk of an immune reaction that may lead to rejection. AutoBT was used at the time of implant placement, simultaneously with o...

In many tissue engineering approaches, the basic difference between in vitro and in vivo conditions for cells within three-dimensional (3D) constructs is the nutrition flow dynamics. To achieve comparable results in vitro, bioreactors are advised for improved cell survival, as they are able to provide a controlled flow through the scaffold. We hypothesize that a bioreactor would enhance long-te...

Bone morphogenetic proteins (BMP) have to be applied at high concentrations to stimulate bone healing. The limited therapeutic efficacy may be due to the local presence of BMP antagonists such as Noggin. Thus, inhibiting BMP antagonists is an attractive therapeutic option. We hypothesized that the engineered BMP2 variant L51P stimulates osteoinduction by antagonizing Noggin-mediated inhibition ...

Intrinsic osteoinductivity—the ability to induce bone formation in ectopic sites without addition of osteogenic factorshas been reported in various porous materials. Tartrate-resistant acid phosphatase (TRAP)-positive osteoclast-like cells are thought to play an important role in material-induced osteoinduction. To investigate the influence of osteoclastic activity on intrinsic osteoinduction, ...

the gamma irradiation has been used for end sterilization of allograft bones and its effects with a 25 kgy dosage on the osteoinductive properties of demineralized bone allograft powder was studied. this work carried out using an experimental method in an animal model. in this study the demineralized bone allograft powder which had been sterilized and prepared with gamma irradiation in a 25 kgy...

The objective of this study is to develop an osteoinductive scaffold which enables the controlled release of bone morphogenetic protein (BMP)-2. A biodegradable gelatin sponge incorporating 50 wt% of btricalcium phosphate (β-TCP) was fabricated to investigate the osteoinduction activity. The sponge prepared had an interconnected pore structure with an average pore size of 200 mm. The in vivo re...