The continuously growing rodent incisor is a widely used model to investigate odontogenesis and mineralized tissue formation. This study focused on evaluating the mouse mandibular incisor as an experimental biological tool for analyzing in vivo the capacity of odontoblast-like progenitors or bioactive molecules to contribute to reparative dentinogenesis. We describe here a surgical procedure al...

Many investigators use bone matrix gelatin for bone induction but it is used rarely for repair of teeth defects. This study was designed to evaluate secondary dentin formation by endochondral bone matrix gelatin (E-BMG) in rabbit. E-BMG was prepared from tibia and femur of 4 Deutsche-Poland rabbits with average ages of 4-6 months. The prepared E-BMG was implanted in right incisor teeth pulps of...

The tooth plates in the living Holocephalan, Chimaera phantasma were studied by various techniques. They consisted of osteodentin and hypermineralized pleromin (kosmin). The degree of mineralization on the latter was as much as in the enameloid of Chondrichthyes and Osteichthyes. Scanning electron microscope observation indicated that the pleromin consisted of large and granular crystals. X-ray...

many investigators use bone matrix gelatin for bone induction but it is used rarely for repair of teeth defects. this study was designed to evaluate secondary dentin formation by endochondral bone matrix gelatin (e-bmg) in rabbit. e-bmg was prepared from tibia and femur of 4 deutsche-poland rabbits with average ages of 4-6 months. the prepared e-bmg was implanted in right incisor teeth pulps of...

The ultimate goal of a regenerative pulp treatment strategy is to reconstitute normal tissue continuum at the pulp-dentin border, regulating tissue-specific processes of tertiary dentinogenesis. Experimental investigations in mature teeth have shown that a network of extracellular matrix molecules and growth factors signal tertiary dentinogenesis. Application of dentin matrix components or grow...

An 18-month-old Japanese boy with multiple natal teeth was examined. Fourteen hard structures were reported to have been present at birth at the regions of the anterior teeth and first primary molars in both jaws. The structures were excessively mobile and 11 of the structures had exfoliated successively since 5 months of age. The three structures remaining at the regions of the first primary m...

We reported previously that Nfic-deficient mice exhibit short and abnormal molar roots and severely deformed incisors. The objective of this study is to address the mechanisms responsible for these changes using morphological, IHC, and RT-PCR analysis. Nfic-deficient mice exhibited aberrant odontoblasts and abnormal dentin formation in molar roots and the labial crown analog of incisors. The mo...

BACKGROUND Nuclear factor I genes play an important role in the development of the brain, lung, and roots of teeth. We had reported that Nfic-deficient mice form normal crowns, but abnormal roots of molar teeth. However, the mechanism by which the disruption of Nfic gene causes abnormal root formation remains unknown. METHODS To understand this mechanism, the root formation in Nfic-deficient ...