Synthetic bone substitutes are used for regeneration of defects and vertical or horizontal augmentation. With the development new manufacturing methodologies such as additive manufacturing, not only can outer shape a scaffold (the macroarchitecture) be personalized, but also microarchitecture, defined distribution material within scaffold, designed optimized ingrowth. Our study assessed optimal...

BACKGROUND Deproteinized bovine bone mineral (DBBM) is one of the best-documented bone substitute materials for sinus floor elevation (SFE). PURPOSE DBBM is available in two particle sizes. Large particles are believed to facilitate improved neoangiogenesis compared with small ones. However, their impact on the rate of new bone formation, osteoconduction, and DBBM degradation has never been r...

PURPOSE To investigate whether ultrasound can stimulate osteoconduction in the mandible, an attempt was made to stimulate the osteoconductive process with low-intensity pulsed ultrasound in rats. MATERIALS AND METHODS In 64 rats, a 5.0-mm diameter circular mandibular defect was made in the ramus and, subsequently, covered on both sides with collagen membranes. Two groups were studied, an ultr...

The topic of bone marrow lesions has been more widely discussed in recent years, especially in the knee literature. One such procedure to treat this pathology is back-filling the lesion with bone substitute materials, calcium phosphate (CaP), as just one example. This technique uses the principle of osteoconduction, CaP mimicking the composition of subchondral bone and creating a scaffold for b...

the gamma irradiation has been used for end sterilization of allograft bones and its effects with a 25 kgy dosage on the osteoinductive properties of demineralized bone allograft powder was studied. this work carried out using an experimental method in an animal model. in this study the demineralized bone allograft powder which had been sterilized and prepared with gamma irradiation in a 25 kgy...

BACKGROUND AND PURPOSE Porous titanium (Ti) particles can be impacted like cancellous allograft bone particles, and may therefore be used as bone substitute in impaction grafting. We evaluated the effect of impaction and of a thin silicated biphasic calcium phosphate coating on osteoconduction by Ti particles. METHODS The bone conduction chamber of Aspenberg was used in goats and filled with ...

If dental implantology is an increasingly successful treatment modality, why should we still need to understand the mechanisms of peri-implant bone healing? Are there differences in cortical and trabecular healing? What does "poor quality" bone mean? What stages of healing are most important? How do calcium phosphate-coated implants accelerate healing? What is the mechanism of bone bonding? Whi...