objective: receptor activator of nuclear factor-kappa b ligand (rankl) appears to be an osteoclast-activating factor, bearing an important role in the pathogenesis of multiple myeloma. some studies demonstrated that u-266 myeloma cell line and primary myeloma cells expressed rank and rankl. it had been reported that the expression of myeloid and monocytoid markers was increased by co-culturing ...

objective: our research attempted to show that mouse dental pulp stem cells (dpscs) with characters such as accessibility, propagation and higher proliferation rate can provide an improved approach for generate bone tissues. with the aim of finding and comparing the differentiation ability of mesenchymal stem cells derived from dpscs into osteoblast and osteoclast cells; morphological, molecula...

objective: average age of population in the industrial countries has increased. because of aging the percent of the diseases related to the oldness such as multiple myeloma have also increased. it has both common and unique symptoms and effects. the unique effects include wide bone reabsorption. it seems necessary to understand the structure of bone marrow niche and the effects of myeloma cells...

The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone. Recently, techniques have been developed to study the cell biology of the osteoclast ...

Osteoclasts seem to be metabolic active during their differentiation and bone-resorptive activation. However, the functional role of lactate dehydrogenase (LDH), a tetrameric enzyme consisting of an A and/or B subunit that catalyzes interconversion of pyruvate to lactate, in RANKL-induced osteoclast differentiation is not known. In this study, RANKL treatment induced gradual gene expression and...

Osteoclasts regulate homeostasis of bone development. A defect in osteoclast development results in osteopetrosis. Recently, the involvement of several molecules in osteoclast development has been found. Osteoclast-associated receptor (OSCAR) is one of such molecules critical for osteoclast differentiation. However, it remains unclear how OSCAR transduces signals for osteoclast differentiation....

Curcumin is known could inhibit the activation of NF-kB, which is important in osteoclast differentiation and activation. The aims of this research were to conduct the effect of curcumin and Pentagamavunon-0 or PGV-0 [2,5-bis-(4’-hydroxy-3’methoxybenzylidene)-cyclopentanone], on osteoclast differentiation and apoptosis. Osteoclast differentiation was carried out using Osteoclast Differentiation...

Receptor activator of NF-kappaB ligand (RANKL) plays an essential role in osteoclast formation and bone resorption. Although genetic and biochemical studies indicate that RANKL regulates osteoclast differentiation by activating receptor activator of NF-kappaB and associated signaling molecules, the molecular mechanisms of RANKL-regulated osteoclast differentiation have not yet been fully establ...

Many miRNAs play critical roles in modulating various biological processes of osteoclast differentiation and function. Microphthalmia-associated transcription factor (MITF), a target of miR-340, served as pivotal transcription factor involved in osteoclast differentiation. However, the role of miR-340 and MITF during osteoclast differentiation has not yet been clearly established. Tartrate-resi...