BACKGROUND Pesticide poisoning is an important cause of morbidity and mortality in India. OBJECTIVES To assess the oxidative damage, hemoglobin level and leukocyte count in acute organophosphorus pesticide poisoning. METHODS Plasma cholinesterase was assessed as a toxicity marker. Oxidative damage was assessed by estimating serum malondialdehyde (MDA) levels, plasma total antioxidant capaci...

This study aimed to observe the clinical curative effect of penehyclidine hydrochloride (PHC) combined with hemoperfusion in treating acute severe organophosphorus pesticide poisoning. We randomly divided 61 patients with severe organophosphorus pesticide poisoning into an experimental group (N = 31) and a control group (N = 30), and we compared the coma-recovery time, mechanical ventilation ti...

Severe organophosphorus or carbamate pesticide poisoning is an important clinical problem in many countries of the world. Unfortunately, little clinical research has been performed and little evidence exists with which to determine best therapy. A cohort study of acute pesticide poisoned patients was established in Sri Lanka during 2002; so far, more than 2000 pesticide poisoned patients have b...

The paper by Aardema and colleagues in this issue of the Netherlands Journal of Medicine illustrates well the problems that clinicians face with organophosphorus pesticide self-poisoning. Yet the toxicological literature’s image of this poisoning is beguilingly simple. Ingestion of an organophosphorus pesticide results in inhibition of acetylcholinesterase. The resulting build up of acetylcholi...

The health hazards of individual organophosphorus insecticides have been characterized by their acute toxicity, mainly by investigating their cholinesterase inhibition. However, the chronic effects of most of these toxicants on the drug-metabolizing enzymes have not been investigated. Profenofos (O-4-bromo-2-chlorophenyl O-ethyl S-propyl phosphorothioate) is an organophosphorus pesticide widely...

In the present scenario, usage of pesticides are inevitable to meet the demands of growing population and to secure the food grain production, there is need for regular screening of milk and milk products for pesticide residues which is being felt in the trade and also at the consumers level. The present work was undertaken to study the effect of heat processing on degradation of various Organo...

Raw buffalo milk samples from the agroindustrial zone in upper Egypt were analyzed for the presence of organochlorine and organophosphorus pesticides using gas chromatography-mass spectroscopy. Five organochlorine pesticides namely, alachlor, dieldrin, hexachlorobenzene, lindane and methoxychlor and three organophosphorus pesticides chlorpyrifos, malathion, and parathion-methyl were detected in...

We used a novel study design to measure dietary organophosphorus pesticide exposure in a group of 23 elementary school-age children through urinary biomonitoring. We substituted most of children's conventional diets with organic food items for 5 consecutive days and collected two spot daily urine samples, first-morning and before-bedtime voids, throughout the 15-day study period. We found that ...

This study investigated the effect of interleukin (IL)-10 on the expression of OX62, MHC-II and CD86 in bone marrow dendritic cells (DCs) in rats with organophosphorus poisoning. Sixty adult SD rats were randomly divided into normal control group (group A) (20 rats), 20 rats with organophosphorus pesticide poisoning (group B), 20 rats with organophosphorus poisoning, and IL-10 treated (group C)...

Pesticides are very hazardous and lethal for organisms as well as for humans. They present danger to consumers, bystanders and workers during manufacture, transport or, during and after use. Pesticides are also toxic to plants and many food crops, including fruits and vegetables, contain pesticide residues after being washed or peeled. Pesticides decrease the biodiversity in soil and it has bee...