Organocopper reagents constitute a key class of organometallic reagents, with numerous applications in organic synthesis [1]. Their high reactivities and chemoselectivities have made them unique intermediates. Most reports use organocopper reagents of type 1 or 2, which are prepared from organolithiums. This transmetalation procedure confers optimal reactivity, but in many cases it permits only...

Mediated by CuCl, 1,4-dilithio-1,3-dienes reacted with carbon monoxide (CO) to generate multi-substituted cyclopentadienones and/or their head-to-head dimers, via tandem CO insertion and intra/intermolecular cycloaddition of organocopper compounds.

The unsupported organocopper pyridine complexes C6F5Cu(py) (2) and [C6F5Cu]2(4,4'-bipy) (3) form supramolecular structures that are unprecedented in organocopper chemistry; one-dimensional chains of copper atoms with Cu...Cu distances of 2.8924(3) angstroms in the blue-luminescent complex are likely associated with cuprophilic interactions, whereas multiple perfluoroarene-arene interactions dom...

We review some applications of copper derivatives as synthetic tools: stoichiometric organocopper reagents and organomagnesium derivatives in the presence of catalytic amounts of copper salts are able to give a regioselective addition on to acetylenic substrates and to alkylate alkyl or vinyl halides, bromohydrines, their tosylates and carboxylates, and a large variety of allylic substrates. IN...

Formation of the first binary stacks of an intact organocopper aggregate with the arenes naphthalene and 2,2'-bithiophene is reported; crystallographic data suggest that the supramolecular assembly process is supported by Cu-pi, Cu-S, and perfluoroarene-arene pi-interactions.