objective nocturnal enuresis is a common childhood problem and has various  treatments. this study was carried out to compare oral and nasal vasopressin in the treatment of nocturnal enuresis in 5- to 12-year-old children who were referred to the shahid beheshti clinic in 2008. materials & methods this study included 100 children (62 males and 38 females) with nocturnal enuresis. one group (50 ...

BACKGROUND We hypothesized that SRX246, a vasopressin V1a receptor antagonist, blocks the effect of intranasally administered vasopressin on brain processing of angry Ekman faces. An interaction of intranasal and oral drug was predicted in the amygdala. METHODS Twenty-nine healthy male subjects received a baseline fMRI scan while they viewed angry faces and then were randomized to receive ora...

Oral administration of the angiotensin I-converting enzyme inhibitor captopril produced a substantial reduction of blood pressure in DOCA-salt hypertensive rats. After oral administration of captopril (30 mg/kg), mean blood pressure decreased from 172 +/- 11 to 148 +/- 9 mmHg (P less than 0.01) in one hour and its antihypertensive effects lasted for the next seven hours. Plasma vasopressin leve...

1. Healthy subjects, given a long-acting preparation of vasopressin intramuscularly, excreted a significantly less concentrated urine than when subjected to fluid deprivation for 28 h. 2. When fludrocortisone, a potent mineralocorticoid, was given in addition to vasopressin the urine was not significantly less concentrated than after fluid deprivation. 3. Oral urea-loading also enhanced the uri...

antagonized by a vascular vasopressin antagonist, which suggests a role for vasopressin in mediating some cardiovascular responses (2). The cardiovascular effects of oral snuff have been examined systematically in only one study (13). Changes in heart rate and blood pressure that are similar in magnitude to those of cigarette smoking were ob served. However, the time course appears to be slower...

Vasopressin (AVP) and oxytocin (OT) receptors (nomenclature as recommended by NC-IUPHAR [94]) are activated the endogenous cyclic nonapeptides vasopressin oxytocin. These peptides derived from precursors which also produce neurophysins (neurophysin I for oxytocin; neurophysin II vasopressin). differ at only 2 amino acids (positions 3 8). There metabolites of these neuropeptides that may be biol...

We studied the contribution of vasopressin to the maintenance of high blood pressure in deoxycorticosterone acetate (DOCA)-salt hypertension in the rat using the nonpeptide orally effective vasopressin VI receptor antagonist OPC-21268. Binding kinetic studies demonstrated that oral OPC-21268 (30 mg/kg) acted as a competitive antagonist at the vasopressin VI receptor in DOCA-salt and salt contro...

The purpose of this study was to examine protein expression of renal aquaporins (AQP) and ion transporters in hypothyroid (HT) rats in response to an oral water load compared with controls (CTL) and HT rats replaced with l-thyroxine (HT+T). Hypothyroidism was induced by aminotriazole administration for 10 wk. Body weight, water intake, urine output, solute and urea excretion, and serum and urin...

context the occurrence of intradialytic hypotension (idh) during hemodialysis (hd) continues to be a main problem in patients with esrd (end-stage kidney disease). it also negatively affects health-related quality of life. we aimed to determine vasopressin effect in decreasing idh. evidence acquisition we reviewed clinical and experimental literature in a variety of sources, including pubmed, c...