a 19-year-old woman was referred to the emergency surgery department with severe abdominal pain, icterus, and anemia. the patient’s clinical and paraclinical findings in addition to her occupational and social history, convinced us to assay blood lead level (bll), which was 41/5 µg/dl. therefore toxicology consult was performed to treat lead toxicity. recheck of the bll showed the level as 53/7...

background: iron chelators are an important part of management of patients with thalassemia. it is prudent to compare efficacy of different iron chelators in treatment of iron overload in these patients who receive regular blood transfusion. we aimed to compare the efficacy and safety of available oral iron chelator; deferasirox (exjade®) with deferasirox (osveral®) in reducing iron overload in...

Neuronal death in Parkinson's disease (PD) is often preceded by axodendritic tree retraction and loss of neuronal functionality. The presence of non-functional but live neurons opens therapeutic possibilities to recover functionality before clinical symptoms develop. Considering that iron accumulation and oxidative damage are conditions commonly found in PD, we tested the possible neuritogenic ...

Over the past four decades, there have been dramatic improvements in survival for patients with thalassemia major due in large measure to improved iron chelators. Two chelators are approved for use in the United States and Canada, parenteral deferoxamine and oral deferasirox. Three are available in much of the rest of the world, where oral deferiprone is also approved (in the United States, def...

background: thalassemia is a chronic, inherited blood disorder, which in its most severe form, causes life-threatening anemia. thalassemia patients not only engage with difficulties of blood transfusion and iron chelating therapy but also have some social challenges and health threatening factors. there are some reports on quality of life in thalassemia patients around the world from southeast ...

A 19-year-old woman was referred to the Emergency Surgery Department with severe abdominal pain, icterus, and anemia. The patient's clinical and paraclinical findings in addition to her occupational and social history, convinced us to assay blood lead level (BLL), which was 41/5 μg/dL. Therefore toxicology consult was performed to treat lead toxicity. Recheck of the BLL showed the level as 53/7...

Bidentate hydroxypyridinone chelators effectively complex and facilitate excretion of trivalent iron. To test the hypothesis that hexadentate chelators are more effective than bidentate chelators at low concentrations, urinary and biliary Fe excretions were determined in Fe-loaded rats before and after administration of a bidentate chelator, Pr-(Me-3,2-HOPO), or its hexadentate analogue, TREN-(...

An expert group of the International Committee on Oral Chelators (ICOC) has recommended a universally effective chelation combination protocol of oral deferiprone (L1) during the day (80-110 mg/kg /day) and subcutaneous deferoxamine (40-60 mg/kg) of a minimum of three nights per week for the rapid, safe and effective depletion of excess body iron in transfused iron loaded patients. Following th...