Introduction: Demyelination is one of the main causes of neurological disability. It is the end product of numerous pathological processes, multiple sclerosis (MS) being the most common cause. More than 70% of the MS patients suffer from optic disturbances. This disease commonly affects the optic pathway, particularly the optic nerves and chiasm. Several attempts have been made to produce a ...

Introduction: Nogo-A and Nogo receptor (NgR) are expressed in the subventricular zone (SVZ) stem cells. NgR plays critical inhibitory roles in axonal regeneration and remyelination. However, the role of NgR in SVZ niche behaviors in demyelination context is still uncertain. Here we investigated the effects of NgR inhibition on SVZ niche reaction in a local model of demyelination in adult mouse ...

introduction: demyelination is one of the main causes of neurological disability. it is the end product of numerous pathological processes, multiple sclerosis (ms) being the most common cause. more than 70% of the ms patients suffer from optic disturbances. this disease commonly affects the optic pathway, particularly the optic nerves and chiasm. several attempts have been made to produce a sui...

The pattern of contralaterally and ipsilaterally projecting retinal ganglion cell (RGC) axons at the optic chiasm is essential for the establishment of binocular vision. Contralateral axons cross the chiasm midline as they progress from the optic nerve to the optic tract. In contrast, ipsilateral axons deviate from the chiasm and continue in the ipsilateral optic tract, avoiding the chiasm midl...

Cavernous hemangioma of the optic chiasm is extremely rare, representing 1% or less of all cavernous hemangioma.1 Klein et al described the earliest reported lesion in 1979.2 Patients typically present with chiasmal apoplexy, characterized by sudden visual disturbance, headache, retro-orbital pain, and nausea.3 Acute dysfunction of the chiasm and/or optic nerve has been called chiasmatic apople...

In animals with binocular vision, retinal fibers either project across the midline or they remain on the same side of the ventral diencephalon, forming an X-shaped commissure known as the optic chiasm. The correct formation of the optic chiasm during development is essential to establish a fully functional visual system. Visual dysfunction associated with axonal misrouting at the optic chiasm h...

Primary malignant gliomas of the optic nerve and chiasm are rare, and are usually rapidly fatal in adults. We report a 48-year-old woman with a glioblastoma multiforme arising from the optic chiasm. Following radiotherapy, our patient survived nearly 14 months, which is the longest survival reported in patients with this diagnosis. There have only been four other reports of glioblastoma multifo...

PURPOSE To develop an objective method for measuring the optic chiasm and to document its normal range in size. METHODS Measurements of the height and area of the optic chiasm, made on coronal T1-weighted MR images with the use of commercially available region-of-interest software, were obtained in 114 healthy subjects who had a total of 123 MR studies. A normal range and standard deviation w...

Figure 1: A. (Top Left) Coronal T2 MRI: Arrowhead showing right cavernous carotid displacing optic chiasm superiorly. Arrow highlighting left ACA displacing the left portion of the optic chiasm inferiorly. Also note focal hyperintensity in the right chiasm. B. (Top Right) Coronal T2 MRI: Arrowhead showing displacement of optic chiasm superiorly by supraclinoid cavernous carotid. C. (Bottom Left...

Nerve fibers originating in the retina follow a specific topographical arrangement in the optic nerve and chiasm. Compressive lesions at the junction of the intracranial optic nerve and optic chiasm can produce characteristic visual field defects. Optic nerve involvement at the junction of the optic chiasm results in unilateral visual field loss. If fibers from the inferonasal retina of the con...