the conventional method towards deriving schedule for a fleet of ships to minimize cost alone has the short-coming of not addressing the problem of operation revenue losses associated with delays during maintenance at ships dockyards. in this paper, a preventive maintenance schedule for a fleet of ships that incorporates op-portunity cost is presented. the idea is to assign a penalty cost to al...

In this paper, a novel methodology is proposed to solve a cooperative multi-depot vehicle routing problem. We establish a mathematical model for multi-owner VRP in which each owner (i.e. player) manages single or multiple depots. The basic idea consists of offering an option that owners cooperatively manage the VRP to save their costs. We present cooperative game theory techniques for cost savi...

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The opportunity cost of the capital invested in pharmaceutical research and development (R&D) to bring a new drug to market makes up as much as half the total cost. However, the literature on the cost of pharmaceutical R&D is mixed on how, exactly, one should calculate this "hidden" cost. Some authors attempt to adopt models from the field of finance, whereas other prominent authors dismiss thi...

A major advantage of Bayesian optimization is that it generally requires fewer function evaluations than optimization methods that do not exploit the intrinsic uncertainty associated with the task. The ability to perform well with fewer evaluations of the target function makes the Bayesian approach to optimization particularly compelling when that target distribution is expensive to evaluate. T...