introduction in spite of the increasing trend in opioid abusers worldwide, the prevalence of narcotic bowel syndrome (nbs) is undetermined. we aimed to estimate the prevalence of nbs and other opioid bowel dysfunction (obd) in opioid abusers in kerman, southeast iran. according to the best of our knowledge, this is the first study to assess the prevalence of nbs in opioid abusers. method by ref...

opioids are widely used for the treatment of malignant and non-malignant pains. these medications are accompanied by adverse effects, in particular gastrointestinal symptoms known as opioid bowel dysfunction (obd). the most common symptom of obd is refractory constipation that is usually stable regardless of the use of laxatives. narcotic bowel syndrome (nbs) is a subset of obd described as amb...

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Opioid analgesics are usually effective in the management of severe chronic pain. However, symptoms of opioid-induced bowel dysfunction (OIBD) are common during opioid therapy. Opioid-induced bowel dysfunction is often unsuccessfully managed due to limited effectiveness and numerous adverse effects of traditional laxatives. Newer treatment possibilities directed at the pathomechanism of OIBD co...

Opioid-induced bowel dysfunction (OIBD) is a collective term used to describe the gastrointestinal side effects of long-term opioid therapy in chronic pain patients. Constipation, nausea, vomiting, bloating, abdominal pain, and gastric reflux are among the most common gastrointestinal adverse effects. Within opioid-induced bowel dysfunction, a more specific subset exists, opioid-induced constip...

Potent opioids are excellent painkillers but their use is hampered by side-effects such as nausea, vomiting, bowel dysfunction, urinary retention, pruritus, sedation and respiratory depression. Co-analgesics are often combined with opioids to reduce the prevalence of these unwanted effects while maintaining or even improve the quality of analgesia. A search of the recent literature demonstrated...

BACKGROUND Strong opioids, including oxycodone, are the most effective analgesics used to combat moderate to severe cancer pain, but opioid-induced bowel dysfunction is a relevant problem associated with the therapy. Clinical studies have demonstrated equivalent analgesic efficacy and improved bowel function in treatment with a fixed combination of prolonged-release (PR) oxycodone and PR naloxo...

Opioid-induced bowel dysfunction (OBD) is characterized by a constellation of symptoms, including constipation; dry, hard stools; straining; and incomplete evacuation. The use of a prophylactic bowel regimen that includes a stimulant laxative and stool softener generally is accepted and should be initiated at the start of opioid therapy. Effective prevention and treatment of OBD reduce the risk...

opium is one of the oldest herbal medicines currently used as an analgesic, sedative and antidiarrheal treatment. the effects of opium are principally mediated by the μ -,κ- and δ-opioid receptors. opioid substances consist of all natural and synthetic alkaloids that are derived from opium. most of their effects on gastrointestinal motility and secretion result from suppression of neural activi...