hub location-allocation problems are currently a subject of keen interest in the research community. however, when this issue is considered in practice, significant difficulties such as traffic, commodity transportation and telecommunication tend to be overlooked. in this paper, a novel robust mathematical model for a p-hub covering problem, which tackles the intrinsic uncertainty of some param...

Recent advances in the ventilation of patients with acute respiratory distress syndrome (ARDS), including ventilation at low lung volumes, have resulted in a decreased mortality rate. However, even low-lung volume ventilation may exacerbate lung injury due to the cyclic opening and closing of fluid-occluded airways. Specifically, the hydrodynamic stresses generated during airway reopening may r...

Single sodium channel currents have been studied in cell-attached patches from the mouse neuroblastoma cell line N1E115. Distributions of open duration, latency until first opening, and the average probability of a channel being open after a voltage step, p(t), were analyzed and compared to predicted distributions from various kinetic models for voltage-dependent gating. It was found that, over...

Objective: To identify which patients benefit from chest reopening after cardiac arrest. Setting: Cardio-thoracic hospital undertaking full range of adult cardio-thoracic surgery. Methods: In-hospital arrests were prospectively audited over a 6-year period. Information was collected for every patient whose chest was reopened following cardiac arrest: location of arrest, type of arrest, specialt...

pressure (r = 0.412, p = 0.042), and the normal saline guttae were correlated not with the opening pressure (r = 0.387, p = 0.101), but rather with the reopening pressure (r = 0.874, p < 0.001). Among the 19 patients, tube ligation (Kee 2001) was performed simultaneously with AGV implantation in two patients due to an intraoperative shallow anterior chamber. In another 17 patients, excluding th...

Airway collapse and reopening due to mechanical ventilation exerts mechanical stress on airway walls and injures surfactant-compromised lungs. The reopening of a collapsed airway was modeled experimentally and computationally by the progression of a semi-infinite bubble in a narrow fluid-occluded channel. The extent of injury caused by bubble progression to pulmonary epithelial cells lining the...