Photo-onycholysis is a phototoxic reaction, which is usually drug-induced. It consists of the separation of the nail from the nail bed due to ultraviolet radiation. We report two cases of female patients who developed distal onycholysis while receiving doxycycline. Among the drugs that cause photo-onycholysis, the most frequently cited are tetracyclines, psoralens and fluoroquinolones. Photo-on...

❚ Splinter hemorrhages If you said onycholysis (left) and red lunula (right), you are correct. As for the underlying diseases: The patient with onycholysis has hyperthyroidism and the patient with red lunula has chronic obstructive pulmonary disease (COPD). Onycholysis and red lunula are among the more common changes to the morphology (shape) and color of the nail—the 2 ways by which nail chang...

Damage to the supporting structures, disruption of the cementing substance binding the nail plate to the surrounding structures or formation of granular layer, which is otherwise absent in a normal nail bed and nail matrix, will produce onycholysis. Trauma from physical factors, manicuring, foreign body implantation or chemicals like solvents, various nail cosmetics and immersion in alkaline so...

Onycholysis, or the separation of the nail from its bed, is a non–lifethreatening toxicity, but one that may impair function and be visibly unpleasant. Anthracyclines and taxanes, alone or in combination, are the cytotoxic drugs most frequently associated with onycholysis (1,2). During the last year, we have treated 36 patients with metastatic colorectal cancer with an irinotecan–capecitabine c...

A case of porphyria cutanea tarda induced by oral contraceptive pill therapy is reported, and its unusual presenting sign of onycholysis of the finger nails is noted. Reference is made to the rarity of nail changes in porphyria and the regression of the onycholysis in the patient following therapy is outlined.

OBJECTIVE To report an unusual reaction associated with weekly administration of paclitaxel. CASE SUMMARIES Onycholysis was seen in four women with recurrent ovarian cancer being treated with low-dose, weekly paclitaxel. Two of the patients had previously received higher doses of paclitaxel on an every-three-week schedule without similar reactions. Onycholysis developed between weeks 10-13 of...

Onycholysis is the detachment of the nail plate from the nail bed. If drug-induced, it can be an isolated phenomenon, but it may also accompany or follow a cutaneous phototoxicity reaction due to drug intake and exposure to ultraviolet irradiation. Photo-onycholysis is a rare photosensitivity reaction due to exposure to either a natural or artificial source of light. Many drugs are responsible ...