background: maturity-onset diabetes of the young (mody) is a heterogeneous entity of monogenic disorders characterized by autosomal dominant inheritance. eleven genes were related, including hnf4α, gck, hnf1α, ipf1, and hnf-1β, and various mutations are being reported. methods: to help the overall understanding of mody-related pathologic mutations, we studied a large mody family found in 2012, ...

Maturity-onset diabetes of the young (MODY) is associated with familially inherited monogenic diabetes. It characterized by genetic mutations leading to pancreatic β-cell dysfunction and subsequent insulin production. Clinical features MODY include young-onset hyperglycemia a lack beta cell autoimmunity or resistance. Glucose-lowering agents are main therapeutic options for MODY. In this review...

Precision medicine, which optimizes diagnosis and treatment of diseases according to individualized characteristics, is becoming a reality in the field diabetes, especially for monogenic diabetes. Maturityonset diabetes young (MODY) type characterized by early onset, relative non-obesity, non-insulin dependence, autosomal dominant inheritance. With trend toward precision medicine improvement ge...

Background Maturity-Onset Diabetes of the Young (MODY) is a form of monogenic diabetes characterized by autosomal dominant inheritance, young age of onset and pancreatic betacell dysfunction without autoimmune cause. To date 13 genes have been identified associated with MODY phenotype, with four of them (HNF1A; GCK; HNF4A and HNF1B) being responsible for over 95% of cases. Recently, our group h...

It is often difficult to identify maturity-onset diabetes of the young (MODY) in pediatric patients close onset. Hence, misdiagnosis and unnecessary insulin treatment are still common.

Maturity onset diabetes of the young (MODY) is a monogenic form of diabetes caused by a mutation in a single gene, often not requiring insulin. The aim of this study was to estimate the frequency and clinical characteristics of MODY at the Barbara Davis Center. A total of 97 subjects with diabetes onset before age 25, a random C-peptide ≥0.1 ng/mL, and negative for all diabetes autoantibodies (...

Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes that is characterized by an early onset, autosomal dominant mode of inheritance and a primary defect in pancreatic β-cell function. MODY represents less than 2% of all diabetes cases and is commonly misdiagnosed as type 1 or type 2 diabetes mellitus. At least 13 MODY subtypes with distinct genetic etiologies have been i...