in this study, the synthesis of 4 h -chromenes of biological activity via a multicomponent reaction of dimedone, aromatic aldehydes and malononitrile catalyzed by glutamic acid as a catalyst was investigated. the structural features of the synthesized compounds were characterized by melting point, ir and 1 h nmr analysis. the catalyst being reported here is cheap, safe to handle and the whole p...

triphenyl phosphine(pph3), an efficient and reusable catalyst, catalysed the synthesis of 2-amino-3-cyano-6-methyl-4-aryl-4h-pyran-5-ethylcarboxylate derivatives by one-pot condensation of aromatic aldehydes, malononitrile and ethyl acetoacetate in etoh-h2o (1:1) at reflux conditions. the results show that aromatic aldehydes containing electron-donating groups or electron-withdrawing groups cou...

amidoalkyl-2-naphthols as synthetic intermediates play an important role in medicinal chemistry due to their remarkable biological and many pharmacological properties. owing to the versatile biological activities, industrial and synthetic applications of these compounds, introduction of an alternative methodology is urgent in synthetic organic chemistry. low yield and harsh reaction conditions ...

Pot-shaped fluorescent aggregates of 6,6-dicyanopentafulvene derivative serve as reactors and stabilizers for the preparation of luminescent ZnO nanoparticles, which exhibit high catalytic efficiency in one-pot multicomponent synthesis of tetrahydropyridines.

An efficient and environmentally benign one-pot condensation of cyclic diketones, aldehydes naphthols was achieved with 1,4-diazabicyclo[2-2-2]octane supported on Amberlyst-15 as a novel catalyst, producing variety benzoxanthenones in good to excellent yields. The advantages this multicomponent reaction include the use heterogeneous solventless conditions simple methodology that is atom-economi...

In this study a multicomponent reaction involving carbohydrate derivatives as the main component in order to prepare a new library of polyhydroxy compounds incorporating pyrimidine-fused heterocycles (PFHs) is introduced. A set of polyhydroxy functionalized PFHs were synthesized using multicomponent reactions of sugar (glucose, galactose, arabinose and lactose), barbituric acid and amines. Also...

A novel multicomponent reaction allowing for a one-pot formation of three carbon-carbon bonds has been developed. It is based on in situ generation and anionic dimerization of methylenedithiane and produces a versatile synthetic equivalent of 4-hydroxy-1,3-alkanediones which, among other things, offers expeditious one-pot access to 3(2H)-furanones.