نتایج جستجو برای: one locus mismatch
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the most important factor in donor-recipient matching for hematopoietic stem cell transplantation is their hla typing. for many patients, we can not find a full-matched donor. in high risk patients, one locus mismatched related donors are suitable alternatives. (1, 2) since the matching of patients and their siblings usually is based on low resolution hla typing, the matching of one locus mism...
this exploratory study aimed to investigate a possible relationship between learners’ beliefs about language learning and one of their personality traits; that is,locus of control (loc). both variables, beliefs and locus of control, are assumed to influence the language learning process. the internal control index (ici) and the beliefs about language learning inventory (balli) were administered...
Gain or loss of repeat motifs leads to an allelic mismatch in the disputed child which is a deviation from Mendelian inheritance, thereby leading paternal putative father exclusion mother case maternal mismatch. This at one more loci major cause forensic inferences. The biological samples were genotyped using Powerplex®- Fusion 5C system kit and Investigator® Argus X-12 QS as per recommendation...
The reported outcome of hematopoietic stem cell transplantation (HSCT) from HLA-mismatched family members has been inconsistent. The object of this study was to evaluate the true impact of HLA-mismatch by using recent data from a homogenous population, excluding HSCT procedures that used graft manipulations, and by considering genotypic matching. Clinical data of 2947 patients who underwent all...
Werner syndrome (WS) is an autosomal recessive disease, the phenotype of which is a caricature of premature aging. WS cells and cell lines display several types of genetic instability, and WS patients have an increased risk of developing cancer. The WS locus (WRN) encodes a protein that shows significant sequence homology to the RecQ family of DNA helicases. Because a DNA helicase may function ...
Spectra of spontaneous mutations at the hypoxanthine-guanine phosphoribosyltransferase (hprt) locus in colon carcinoma cell lines HCT116 and HCT-15 deficient in mismatch repair and displaying mutator phenotypes were determined. HCT116 and HCT-15 cells, respectively, harbour a mutation in the mismatch repair gene hMLH1 and GTBP. The mutation frequency at the hprt locus in both cell lines was ele...
We have studied the outcome of 211 consecutive unrelated donor (URD) bone marrow transplants (BMT) performed at the University of Minnesota (Minneapolis, MN) between May 1985 and December 1992. Ninety patients (43%) received marrow matched serologically at HLA A, B, and DR loci; 86 (41%) received marrow with a major and 32 (15%) marrow with a minor serologic mismatch at the HLA A or B locus. Mu...
During meiotic recombination in the yeast Saccharomyces cerevisiae, heteroduplexes are formed as an intermediate in the exchange process. In the formation of an asymmetric heteroduplex, one chromosome acts as a donor of a single DNA strand and the other acts as a recipient. We present genetic evidence that the nontranscribed strand is donated more frequently than the transcribed strand in spore...
3. CHALLENGES FOR COMPOSITIONALITY 3.1. TYPE MISMATCH 3.1.1. Quantifier interpretation 3.1.2. Real-time processing of quantified expressions 3.1.3. Type mismatch in conjunctions 3.2. COERCION 3.2.1. Complement coercion 3.2.2. Coercion as VP-insertion 3.2.2.1. Evidence in favor of VP-insertion 3.2.2.2. Evidence against VP-insertion 3.2.3. Real-time processing of complement coercion 3.2.3.1. Basi...
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