Chronic toxicity, rat: No data gap, no adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, no adverse effect Oncogenicity, mouse: No data gap, no adverse effect Reproduction, rat: No data gap, no adverse effect Teratology, rat: No data gap, no adverse effect Teratology, rabbit: No data gap, no adverse effect Gene mutation: No data gap, no adverse...

Chronic toxicity, rat: No data gap, no adverse effect indicated. Chronic toxicity, dog: No data gap, no adverse effect indicated. Oncogenicity, rat: No data gap, no adverse effect indicated. Oncogenicity, mouse: No data gap, no adverse effect indicated. Reproduction, rat: No data gap, no adverse effect indicated. Teratology, rat: No data gap, no adverse effect indicated. Teratology, rabbit: No ...

plasmid DNA. Those fragments represent the homologous Ti-plasmid DNA segment 8,um long (1 5 % of the Ti-plasmid). An argument that this region of the plasmid contains genes essential for the expression of oncogenicity came from the analysis of a deletion mutant in the Ti-plasmid (Hernalsteens et al., 1975). Since this deletion mutant is unable to confer oncogenicity and has lost exactly those t...

Chronic toxicity, rat: No data gap, possible adverse effect Chronic toxicity, dog: No data gap, no adverse effect indicated Oncogenicity, rat: No data gap, no adverse effect indicated Oncogenicity, mouse: No data gap, no adverse effect indicated Reproduction, rat: No data gap, no adverse effect indicated Teratology, rat: No data gap, no adverse effect indicated Teratology, rabbit: No data gap, ...

Chronic toxicity, rat: No data gap, no adverse effects Chronic toxicity, dog: No data gap, no adverse effects Oncogenicity, rat: No data gap, no adverse effects Oncogenicity, mouse: No data gap, no adverse effects Reproduction, rat: No data gap, no adverse effects Teratology, rat: No data gap, no adverse effects Teratology, rabbit: No data gap, no adverse effects Gene mutation: No data gap, pos...

Chronic toxicity, rat: No data gap, possible adverse effect Chronic toxicity, dog: No data gap, no adverse effect Oncogenicity, rat: No data gap, possible adverse effect Oncogenicity, mouse: No data gap, no adverse effect Reproduction, rat: No data gap, no adverse effect Teratology, rat: No data gap, no adverse effect Teratology, rabbit: No data gap, no adverse effect Gene mutation: No data gap...

C ell lines and derived clones o f the m ouse plasm acytom a M OPC-315 w ere analyzed for: (1) oncogenicity in vivo , (2) doubling tim es in vitro , (3) differences in im m unoglobulin structure and secretion and (4) viral enzym e activity. Seven clones derived from the J27-3a line of M OPC-315 w ere less on­ cogenic than the original tum or and th e p aren t cell line. F our caused 80 to 90 p ...