background: melanoma causes the greatest morbidity and mortality of all skin cancers. mucosal melanoma is a rare but highly aggressive neoplasm. according to previous studies the prevalence of kit mutations in acrallentiginous and mucosal melanomas is relatively low (less than 15–20%), but it can have profound therapeutic implications for localized high risk or metastatic diseases. our goal was...

materials and methods twelve natural compounds jaceosidin, withaferin a, curcumin, epigallocatechin-3-gallate (egcg), artemisinin, gingerol, ursolic acid, ferulic acid, berberin, silymarin, resveratrol, and indol-3-carbinol were docked against e6 and e7 oncoproteins of high-risk hpv types 16 and 18 using a protein-ligand docking software called autodock4.2. results out of these 12 natural compo...

transforming growth factor atpha (tgf-a), parathyroid hormone-tike proteins (pthlp) and oncogene p53 proteins have all been demonstrated in a variety of human tumors anil have been implicated as causes of tumor cell aggressiveness. the present study determined the existence of these peptides and their immunohistochemicat profiles in ameloblastomas. odontogenic keratocysts and dentigerous cysts ...

Proto-oncogenes are the genes that have potential to transform normal cells into cancer as a result of mutations. They usually contain encoding proteins whose function is inhibit cell differentiation, stimulate division, and prevent death cells. While prognosis regarding proto-oncogene may occur at varying phases cancer, accuracy identification method always questionable. The standard procedure...

Abstract This invited Team Profile was created by Kevin Li and Liliya Yatsunyk, Swarthmore College PA (USA) John Schneekloth, Jr, (Jay) National Cancer Institute, Frederick MD . They recently published an article on the first crystal structure of intercalated motif (i‐motif or iM) from HRAS oncogene involved in many cancers. The iHRAS solved to 1.8 Å resolution. It contains a tail‐to‐tail dimer...

The malignant lung cancer has a high morbidity rate and very poor 5-year survival rate. About 80% - 90% of protein degradation in human cells is occurred through the ubiquitination enzyme pathway. Ubiquitin ligase (E3) with specificity plays crucial role process target protein, which usually occurs at lysine residue substrate protein. Different forms have different effects on proteins. Multiple...

micrornas are 19-22 nucleotide rnas involved in such important processes as development, proliferation, differentiation and apoptosis. different mirnas are uniquely expressed in lymphoid t cells, and play a role indevelopment and differentiation of various subtypes by targeting their target genes. recent studies have shown that aberrant mirna expression may be involved in t cell leukemogenesis ...