Male infertility is a common human reproductive defect that can be resulted from spermatogenesis impairment. DMRT1 encodes a male-specific transcriptional regulator and is important for human spermatogenesis. This study was designed to explore the relationship between the Single Nucleotide Polymorphism (SNP) of DMRT1 and oligospermia. Two SNPs namely rs3739583 and rs4742608, were screened in 21...

AIM To investigate the association of glutathione S-transferase T1 (GSTT1) gene polymorphism in patients with idiopathic azoospermia or oligospermia in the northwestern China population. METHODS In the case-control study, GSTT1 genotypes were identified by multiplex polymerase chain reaction (PCR) with peripheral blood DNA samples from 78 patients with idiopathic azoospermia, 103 patients wit...

In Pakistan, male infertility constitutes about 35% of all cases of infertility. The dysfunction can be at the level of the central nervous system or somewhere in the male genital tract. A study was conducted to screen cases of male infertility using various biochemical parameters. A total of 81 cases were screened. Oligospermia was seen in 13 (16%) patients. They were divided into severe and m...

Oligospermia in an otherwise clinically normal man, is one of the commonest conditions encountered in an infertility clinic. Medical management of oligospermia lags far behind expectations, and is still in an experimental stage. Efforts have been made to improve the semen picture of patients with the administration of hormones like testosterone, gonadotrophins or the ovulatory drug, Clomiphene ...

PURPOSE The purpose of this study is to evaluate the preoperative factors that influenced postoperative sperm concentration after vasovasostomy. MATERIALS AND METHODS We retrospectively reviewed 97 consecutive single-layer vasovasostomy procedures performed by a single surgeon between March 2003 and September 2010. The patients were stratified into three groups based on sperm concentration at...

Oligospermia is a major cause of infertility in couples. It is usually managed by assisted reproductive techniques. In these techniques the female partners are treated, while the male partners having this medical problem are left untreated! Though several empirical therapies are available to treat oligospermia, it is difficult to identify a therapy that is most likely to benefit a man having ol...

OBJECTIVE To determine an unusual complex chromosome rearrangement found in a man with oligospermia with a normal phenotype. DESIGN Case report with a review of the literature. SETTING Academic research environment. PATIENT(S) A man with oligospermia but otherwise apparently healthy. INTERVENTION(S) Peripheral blood lymphocytes were used for karyotyping, and metaphases were analyzed by ...

The aim of this study was to investigate the roles of oxygen free radicals and mitochondrial signaling in semen disorders, in particular, how this induces low concentrations and reduced motility of sperm. Ejaculate samples were obtained from 120 young adult males (mean age, 28.7±5.3 years) with normal semen (n=30), oligospermia (n=30), asthenospermia (n=30) and oligoasthenozoospermia (n=30). Th...