oligoclonal bands (ocb) can be detected in a significant percentage (90%) of patients with multiple sclerosis (ms), however, a much lower percentage has been reported in some studies, mainly from oriental countries. on the other hand, ocb have been detected in other neurological disorders (ond), even in diseases without any definite evidence for inflammation in csf such as myasthenia gravis. th...

BACKGROUND Oligoclonal free kappa bands are present as frequently as oligoclonal IgG bands in the cerebrospinal fluid (CSF) from patients with definite multiple sclerosis (MS) and can even occur in the absence of oligoclonal IgG. As such, they too are markers of an ongoing intrathecal immune process. OBJECTIVES To determine how frequently oligoclonal free kappa bands are detectable in the CSF...

Background: Oligoclonal free kappa bands are present as frequently as oligoclonal IgG bands in the cerebrospinal fluid (CSF) from patients with definite multiple sclerosis (MS) and can even occur in the absence of oligoclonal IgG. As such, they too are markers of an ongoing intrathecal immune process. Objectives: To determine how frequently oligoclonal free kappa bands are detectable in the CSF...

A recent paper (1) describing oligoclonal banding in CSF indicates that it is necessary to electrophorese paired CSF and serum specimens simultaneously, to differentiate oligoclonal banding caused by intrathecal iinmunoglobulun production from increased permeability of the blood-CSF barrier. This dogma is not correct, as it has been shown by use of polyacrylaimde gel isoelectric focusing and Co...

Agarose isoelectric focusing was used to demonstrate oligoclonal bands in cerebrospinal fluid (CSF) and serum from 998 consecutive neurological patients. Compared with agarose electrophoresis, agarose isoelectric focusing was slightly more sensitive, showing more (and more easily discernible) oligoclonal bands. Agarose isoelectric focusing, which has good reproducibility, revealed oligoclonal b...

A recent paper (1) describing oligoclonal banding in CSF indicates that it is necessary to electrophorese paired CSF and serum specimens simultaneously, to differentiate oligoclonal banding caused by intrathecal iinmunoglobulun production from increased permeability of the blood-CSF barrier. This dogma is not correct, as it has been shown by use of polyacrylaimde gel isoelectric focusing and Co...

BACKGROUND The emergence of oligoclonal bands, proteins differing from those originally identified at diagnosis, has been reported in multiple myeloma patients after high-dose chemotherapy followed by autologous stem cell transplantation and after successful conventional chemotherapy. The clinical relevance of oligoclonal bands remains unclear, but their emergence has been associated with bette...

The relationship between two tests commonly used in the investigation of multiple sclerosis (MS), the IgG index and oligoclonal bands, has been assessed. Using an immunoblotting technique specific for IgG, analysis of cerebrospinal fluid for oligoclonal bands was found to provide greater diagnostic sensitivity than the IgG index without any loss of specificity. In patients without oligoclonal b...

OBJECTIVE To investigate the incidence and characteristics of patients with structural central nervous system (CNS) lesions and cerebrospinal fluid oligoclonal IgG bands. DESIGN A retrospective study. METHOD The medical records of patients with cerebrospinal fluid oligoclonal IgG bands were evaluated for the presence of structural CNS lesions, their location and cause, and for clinical char...