Neural network (NN)-based modeling often involves trying multiple networks with diierent architectures and training parameters in order to achieve acceptable model accuracy. Typically, one of the trained NNs is chosen as best, while the rest are discarded. Hashem and Schmeiser 25] proposed using optimal linear combinations of a number of trained neural networks instead of using a single best ne...

Neural network-based modeling often involves trying multiple networks with different architectures and training parameters in order to achieve acceptable model accuracy. Typically, one of the trained networks is chosen as best, while the rest are discarded. [Hashem and Schmeiser (1995)] proposed using optimal linear combinations of a number of trained neural networks instead of using a single b...

We describe an approach to healthcare coordination using object life cycles (OLCs) [1]. By consulting the OLC of a given patient object instance, the legal methods to apply to that object at that time can be identified – acting as a resource for a clinical workstation accessing the Internet-based instance stored by the host of the interorganisational hospital information system (HIS). To suppor...

Characterizing and enumerating cells of the oligodendrocyte lineage (OLCs) is crucial for understanding demyelination and therapeutic benefit in models of demyelinating disease in the central nervous system. Here we describe a novel method for the rapid, unbiased analysis of mouse OLCs using flow cytometry. The assay was optimized to maximize viable yield of OLCs and maintain OLC antigen integr...

BACKGROUND Retinoic acid (RA) signaling has been identified as a key driver in male and female gamete development. The presence of RA is a critical step in the initiation of meiosis and is required for the production of competent oocytes from primordial germ cells. Meiosis has been identified as a difficult biological process to recapitulate in vitro, when differentiating stem cells to germ cel...

BACKGROUND K(V)7/KCNQ channels are widely expressed in neurons and they have multiple important functions, including control of excitability, spike afterpotentials, adaptation, and theta resonance. Mutations in KCNQ genes have been demonstrated to associate with human neurological pathologies. However, little is known about whether K(V)7/KCNQ channels are expressed in oligodendrocyte lineage ce...

The behavioral-inheritance relations of [7, 8] can be used to compare the life cycles of objects de ned in terms of Petri nets. They yield partial orders on object life cycles (OLCs). Based on these orders, we de ne concepts such as the greatest common divisor and the least common multiple of a set of OLCs. These concepts have practical relevance: In component-based design, work ow management, ...

A comprehensive model that delineates the interrelationships among computer systems, organizational context and organizational learning is absent. This study aims to fill this void. Unlike previous research, this study investigates the role of computer systems, i.e. organizational learning computer systems (OLCS), in facilitating organizational learning. In our framework, we argued that context...

BACKGROUND Demyelination is a common lesion in spinal cord injury, cell therapy is one of the approaches for replacing the lost oligodendrocytes. In this study, bone marrow stromal cells (BMSCs) have been transdifferentiated into oligodendrocyte-like cells (OLCs) and used in cytotherapy of contused spinal cords in rats. METHODS The BMSCs were collected from the rat long bones, and cultured an...