Oral immunotherapy (OIT) has been considered a promising approach for food allergies (FAs). However, the current OIT strategy is limited in terms of the long-term efficacy and safety. We have previously demonstrated that kakkonto, a traditional Japanese herbal medicine, suppresses the occurrence of allergic symptoms in a murine model of ovalbumin (OVA)-induced FA, which is attributed to the ind...

Oral immunotherapy (OIT) is a promising therapeutic approach for treating food allergy. Past studies have shown that OIT reduces allergic response only in severe allergy model mice. We worked to establish mild allergy model mice, and investigated whether 'rush' OIT for 10 d improved the allergic response and biomarkers in these mice. Balb/c mice were sensitized to ovomucoid (OM) in alum. The ru...

Background Food allergies are a problematic health concern in many developed countries. Oral immunotherapy (OIT) is one of the most promising therapeutic approaches for treating food allergy. The treatment with heated ovomucoidreduced egg white (OM ̅) is especially notable and its effectiveness as OIT in egg allergic patients has been reported: 24 (44%) egg allergic patients became tolerant afte...

Oral immunotherapy (OIT) has been introduced as a new immune-modulating treatment under investigation for food allergies. The aim of our study was to evaluate the success of OIT in a cohort of children with milk allergy. These children underwent OIT in a clinical practice and were followed for up to ten years. The secondary endpoint was to describe the main adverse events during OIT and compare...

Food allergen oral immunotherapy (OIT) is an experimental, immune-modifying therapy that may induce clinical desensitization in some patients. OIT is still in early phase clinical research, but some providers may offer OIT as a clinical service. To understand the current practices of allergists who perform OIT, an online survey was sent by e-mail to members of the American Academy of Allergy As...

BACKGROUND Oral immunotherapy (OIT) has shown promise in inducing desensitization for food allergy. However, there are safety concerns regarding the frequency and severity of adverse events during food OIT. OBJECTIVE To evaluate the effect of Ketotifen premedication on adverse reactions during peanut OIT. METHODS A randomized single blind placebo controlled pilot study was performed. Peanut...

Oral immunotherapy (OIT) is used regularly for young children with cow's milk (CM) allergy and has been shown to be effective in several studies. However, adverse events occur frequently during OIT. Furthermore, there are only 5 randomized controlled trial studies of CM-OIT and these are low-powered single center trials. Therefore, evidence levels are also low and sometimes frequent and severe ...

METHODS. This study was a randomized, placebo-controlled trial with subjects randomly assigned to milk or placebo OIT. OIT was administered in 3 phases: (1) initial build-up day; (2) daily home dosing with 8 weekly, in-office, dose increases; and (3) continued home daily maintenance dosing (500 mg) for 13 weeks. Before and after OIT, subjects had double-blind, placebo-controlled, food challenge...

Amongst others, 2-octyl-isothiazol-3(2 H)-one (OIT) is used as film preservative in water-based polymer resin paints and renders to prevent the growth of moulds and bacteria. It is known that biocides leach from facades with rainwater and end up in the environment via stormwater runoff. In the present study the leaching and fate of OIT used in facade coatings was determined under natural condit...

Results We identified one RCT with 28 children age 1-16 years (19 in the OIT group and nine in the placebo group). Because of allergic side-effects, three children were withdrawn from the OIT group early in the study. The remaining 16 participants in the OIT group completed the study and ingested a maximum cumulative dose (MCD) of 5000 mg (≈20 peanuts). All 9 participants in the placebo group c...