regional odontodysplasia (ro) is a rare developmental dental anomaly with an unknown etiology. it is more often seen in girls than boys. treatment of ro depends on the individual case. the aims of treatment should include aiding mastication and speech, improving aesthetics, reducing the psychological impact of the anomaly, allowing normal jaw growth and development, and if possible protection o...

The word “odontodysplasia” was coined by Zegarelli, et al. (1963). Because this abnormality has a tendency to affect only one quadrant, “regional odontodysplasia” became the most accepted term to define it. The same condition has been described under other denominations, such as “odontogenic dysplasia, “localized arrested tooth development” “ghost teeth, “odontogenesis imperfecta”, “unilateral ...

Dentinogenesis imperfecta is a dominant autosomal hereditary disorder of dentin formation that affects the deciduous and permanent teeth. Its etiology is characterized by inadequate cell differentiation during odontogenesis. The clinical characteristics of dentinogenesis imperfecta are discolored teeth with a translucency that varies from gray to brown or amber. Radiographically, the teeth exhi...

Odontogenesis is a highly co-ordinated and complex process which relies upon cell-cell interactions that result in the initiation and generation of tooth. Molecular changes that correlate with advancing tooth morphogenesis have been mapped by many research groups. Here, we review some of the current literature concerning molecular regulation of odontogenesis. Key-Words: Odontogenesis; tooth for...

There has been growing recognition of the essential roles of citrate in biomechanical properties of mineralized tissues, including teeth and bone. However, the sources of citrate in these tissues have not been well defined, and the contribution of citrate to the regulation of odontogenesis and osteogenesis has not been examined. Here, tooth and bone phenotypes were examined in sodium-dependent ...

Odontogenesis results from the continuous and reciprocal interaction between cells of the oral epithelium and cranial neural crest-derived mesenchyme. The canonical Wnt signaling pathway plays a fundamental role in mediating these interactions from the earliest stages of tooth development. Here we analyze by in situ hybridization the expression patterns of the extracellular Wnt antagonist Frzb/...

Osteogenesis imperfecta presents with unique challenges to the anaesthetist. We report a case of osteogenesis imperfecta, posted for rush rodding femur managed caudal anaesthesia and sedation dexmedetomidine ketamine.

Rapid increase of knowledge in stem cell research, bioengineering technology and molecular basis of odontogenesis has finally lead us to the point where it is possible to develop approaches for treatment of tooth loss with bioengineered teeth, which one day might completely replace conventional prosthodontics and dental implants. By holding onto the premise that in order to bioengineer teeth, f...

Important factors involved in odontogenesis in mouse dental papillae disappear between the pre- and post-natal stages of development. Therefore, we hypothesized that certain genes involved in odontogenesis in dental papillae were subject to pre-/post-natal down-regulation. Our goal was to identify, by microarray analysis, which genes were down-regulated. Dental papillae were isolated from embry...

Dentin sialoprotein (DSP) is essential for dentinogenesis and processed into fragments in the odontoblast-like cells and the tooth compartments. Matrix metalloproteinase 9 (MMP9) is expressed in teeth from early embryonic to adult stage. Although MMP9 has been reported to be involved in some physiological and pathological conditions through processing substrates, its role in tooth development a...