the histopathologic diagnosis of orbital and ocular adnexal lymphoproliferative lesions is difficult, resulting controversy in classification, determining benignity or malignancy of them and treatment modality selection. we designed the following study to evaluate clinical, histopathologic and if necessary immunochemical features of them in decreasing indeterminate cases. the study includes 51 ...

We investigated the organization of the immunoglobulin heavy chain (IgH) and the T cell receptor beta chain (T$) gene loci in 20 ocular adnexal and four extraocular lymphoid neoplasms obtained from 1 8 patients presenting with an ocular adnexal lymphoid neoplasm. Fifteen ocular adnexal and four extraocular lymphoid neoplasms occurring in 1 3 patients were classified by morphological examination...

We investigated the organization of the immunoglobulin heavy chain (IgH) and the T cell receptor beta chain (T$) gene loci in 20 ocular adnexal and four extraocular lymphoid neoplasms obtained from 1 8 patients presenting with an ocular adnexal lymphoid neoplasm. Fifteen ocular adnexal and four extraocular lymphoid neoplasms occurring in 1 3 patients were classified by morphological examination...

We investigated the organization of the immunoglobulin heavy chain (IgH) and the T cell receptor beta chain (T beta) gene loci in 20 ocular adnexal and four extraocular lymphoid neoplasms obtained from 18 patients presenting with an ocular adnexal lymphoid neoplasm. Fifteen ocular adnexal and four extraocular lymphoid neoplasms occurring in 13 patients were classified by morphological examinati...

PURPOSE We identified the genomic signature of ocular adnexal lymphoproliferative disorders (LPDs), especially ocular adnexal mucosa-associated lymphoid tissue (MALT) lymphoma, IgG4-related ophthalmic disease (IgG4-ROD), reactive lymphoid hyperplasia (RLH), and diffuse large B-cell lymphoma (DLBCL). METHODS We included 52 subjects with ocular adnexal LPDs (13 orbital MALT lymphomas, 16 conjun...

Ocular adnexal non-Hodgkin's lymphoma (NHL), the most common form of ophthalmic NHL, has a unique incidence pattern showing a steady and rapid increase in the past few decades, nearly equal rates among both genders, and predominance among Asians/Pacific Islanders. No major cause for ocular adnexal NHL has been identified, although infectious agents, immune disorders and genetic/epigenetic facto...

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Ocular Adnexal Lymphomas are the first cause of primary ocular malignancies, and among them the most common are MALT Ocular Adnexal Lymphomas. Recently systemic immunotherapy with anti-CD20 monoclonal antibody has been investigated as first-line treatment; however, the optimal management for MALT Ocular Adnexal Lymphomas is still unknown. The present study evaluated retrospectively the outcome ...

In this article, we provide an update on incidence rates of ophthalmic non-Hodgkin's lymphoma (NHL), in the context of other NHL, in the USA. We also provide population-based estimates of incidence and survival for ocular adnexal NHL, the most common form of ophthalmic NHL, for which descriptive patterns have not been previously reported. Ophthalmic and ocular adnexal NHL have unique incidence ...