The surfaces of hydoxyapatite ceramics were modified by the precipitation of octacalcium phosphate coating from aqueous solution and the biomimetic method synthesized nanohydroxyapatite coatings. Both coatings were deposited as continuous and uniform layers. It was demonstrated that the octacalcium phosphate coating was inappropriate for in-vitro osteoblast proliferation despite of good initial...

It was demonstrated that octacalcium phosphate collagen composite achieved notable bone regeneration in bone defects in preclinical studies. On the basis of the research results, an investigator-initiated exploratory clinical trial was conducted after approval from a local Institutional Review Board. This clinical study was performed as a single-arm non-randomized intervention study. Octacalciu...

The osteoconductive and possibly osteoinductive characteristics of OCP increased the interest in preparation of bone graft materials that contain OCP in its composition. Calcium phosphate cements (CPCs) were prepared using a mixture of α-tricalcium phosphate (α-TCP) and dicalcium phosphate anhydrous (DCPA), with α-TCP / DCPA molar ratio of 1/1 and distilled water or 0.5 mol / L phosphate aqueou...

Conclusions: Crystals forming mineral blocks of mostly compact matter are nucleated on organic substrates, with their growth controlled by the diffusion of building units through the virtually stagnant layer of interstitial fluid wetting the deposit surface. Preferentially formed precursors of hydroxyapatite, dicalcium, octacalcium and/or amorphous calcium phosphate, are in later stages of depo...

We report the creation of motif-based artificial proteins that bind to titanium surfaces and mediate the deposition of crystalline calcium phosphate. These proteins enabled in aqua surface modification of titanium materials having an intricate structure used in medical applications.

Biocompatible calcium phosphate ceramic grafts are able of supporting new bone formation in appropriate environment. The major limitation of these materials usage for medical implants is the absence of accessible methods for their patient-specific fabrication. 3D printing methodology is an excellent approach to overcome the limitation supporting effective and fast fabrication of individual comp...

The aim of the present study was to evaluate the effects of experimental saliva substitutes based on carboxymethyl cellulose (CMC) differing in degrees of saturation with respect to calcium phosphates on the mineral loss of enamel in vitro. Demineralized bovine specimens (subsurface lesions) were exposed to one of six experimental CMC-based solutions with theoretical degrees of saturation with ...