نتایج جستجو برای: ochronosis

تعداد نتایج: 209  

Journal: :Dermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.] 2004
Supriya G Bellew Tina S Alster

BACKGROUND Exogenous ochronosis is a cutaneous disorder characterized by blue-black or slate-gray hyperpigmentation resulting from the prolonged use of certain topical agents, most commonly hydroquinones. It is notoriously difficult to treat. OBJECTIVE To report the effectiveness of a quality-switched (QS) 755-nm alexandrite laser in treating hydroquinone-induced exogenous ochronosis. METHO...

Journal: :Archives of Internal Medicine 1922

Journal: :Bulletin of the NYU hospital for joint diseases 2011
Obafunto Abimbola Greg Hall Joseph D Zuckerman

Alkaptonuria is a rare disease in which a deficiency in the homogentisate 1, 2-dioxygenase enzyme results in a buildup of homogentisic acid. Ochronosis, the deposition of excess homogentisic acid in connective tissue, causes brownish-black pigmentation and weakening of the tissue ultimately resulting in chronic inflammation, degeneration, and osteoarthritis. There is currently no definitive cur...

Journal: :AANA journal 2005
E Collins Rick Hand

Alkaptonuric ochronosis is a rare autosomal recessive metabolic disorder resulting in a deficiency of homogentisic acid oxidase (alkaptonuria). Ultimately, this enzyme deficiency enables homogentisic acid to accumulate, become polymerized, and be systemically deposited within various tissues of the body (ochronosis). As the disease progresses, tissue deposition of polymerized homogentisic acid ...

Journal: :Collegium antropologicum 2007
Porin Perić Bozidar Curković Kristina Potocki Durda Babić-Naglić Sanja Perić Branimir Cerovski Tatjana Kehler Tomislav Vidović

We describe a 49-year-old man with coexistence of ochronosis and B27 positive ankylosing spondylitis. This is the first report documenting the simultaneous occurrence of ochronosis and B27 positive ankylosing spondylitis, with no positive familiar history for seronegative spondylarthropathies. The relations of these rheumatic diseases are discussed.

2015
Vaibhav G. Patel

Alkaptonuria is disorder of tyrosine metabolism due to deficiency of homogentisic oxidase characterized by excretion of homogentisic acid in urine, deposition of oxidized homogensitate pigments in connective tissues and articular cartilages (ochronosis). The result is dark pigmentation and weakening of the tissues resulting in chronic inflammation and osteoarthritis. Management of alkaptonuric ...

2009
Andreas Wilke Dietmar Steverding

INTRODUCTION Alkaptonuria (also known as ochronosis) is a genetic disorder characterised by the accumulation of homogentisic acid deposits in connective tissue. In rare cases, ochronosis can cause valvular heart disease. CASE PRESENTATION We present the case of a 68-year-old Caucasian man with alkaptonuria-associated degenerative valvular defects with aortic, mitral and tricuspid valve insuff...

Journal: :Journal of the American Academy of Dermatology 2007
Jacob Levitt

Recently, the US Food and Drug Administration proposed a ban on over-the-counter hydroquinone mainly on the basis of high absorption, reports of exogenous ochronosis in humans, and murine hepatic adenomas, renal adenomas, and leukemia with large doses over extended time periods. Systemic exposure to hydroquinone from routine topical application is no greater than that from quantities present in...

Journal: :Deutsches Aerzteblatt Online 2018

2014
Oguz Cebesoy Mustafa Isik Mehmet Subasi Abbas Kaya Fethi Bilgin Oğuz Kaya

PATIENT Male, 46 FINAL DIAGNOSIS: Akkaptonuria Symptoms: Hip pain Medication: - Clinical Procedure: Total hip replacement Specialty: Orthopedics and Traumatology. OBJECTIVE Unusual or unexpected effect of treatment. BACKGROUND Ochronosis is an inherited metabolic disease in which there is an accumulation of excessive amounts of homogentisic acid in the connective tissue. As the disease prog...

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