Mouse inbred strains B10.O20 and O20 were used to study the genetics of susceptibility to small intestinal cancer. Strain B10.O20 is susceptible to tumors of the small intestine induced by a transplacental treatment with the carcinogen N-ethyl-N-nitrosourea on day 18 of gestation, whereas strain O20 is completely resistant. F1 hybrid mice are also completely resistant, indicating that homozygos...

Mouse inbred strains B10.O20 and O20 were used to study the genetics of susceptibility to small intestinal cancer. Strain B10.O20 is susceptible to tumors of the small intestine induced by a transplacental treatment with the carcinogen N-ethyl-/V-nitrosourea on day 18 of gestation, whereas strain O20 is completely resistant. F, hybrid mice are also completely resistant, indicating that homozygo...

A primary factor in controlling and preventing obesity is through dietary manipulation. Diets higher in protein have been shown to improve body composition and metabolic health during weight loss. The objective of this study was to examine the effects of a high-protein diet versus a moderate-protein diet on muscle, liver and fat metabolism and glucose regulation using the obese Zucker rat. Twel...

Although several genes that cause monogenie familial cancer syndromes have been identified, susceptibility to sporadic cancer remains unresolved. Animal experiments have demonstrated multigenic control of tumor suscep tibility. Recently, we described four mouse lung cancer susceptibility (Slue) loci, the main effects of which are masked by their mutual interactions. Because such interactions ca...

Interferon-induced GTPases [guanylate-binding proteins (GBPs)] play an important role in inflammasome activation and mediate innate resistance to many intracellular pathogens, but little is known about their role in leishmaniasis. We therefore studied expression of Gbp2b/Gbp1 and Gbp5 mRNA in skin, inguinal lymph nodes, spleen, and liver after Leishmania major infection and in uninfected contro...

Although several genes that cause monogenie familial cancer syndromes have been identified, susceptibility to sporadic cancer remains unresolved. Animal experiments have demonstrated multigenic control of tumor suscep tibility. Recently, we described four mouse lung cancer susceptibility (Slue) loci, the main effects of which are masked by their mutual interactions. Because such interactions ca...

The present authors explored the relationship between asthma control status, as measured by a derived Asthma Control Test (ACT) score, and the utilisation and cost of healthcare in Europe. Data were derived from a European survey of asthma patients. Frequency of healthcare resource use was identified from the dataset and per-patient mean cost of asthma management estimated. Drug costs were not ...

A novel agarolytic gammaproteobacterium, ITALIC! Paraglaciecolasp. S66, was isolated from marine samples of eelgrass ( ITALIC! Zosterasp.) and sequenced. The draft genome contains a large number of enzyme-encoding genes with predicted function against several complex polysaccharides found in the cell walls of algae.

Low-energy dipole (LED) excitations in $^{20}\mathrm{O}$ were investigated by variation after $K$ projection of $\mathrm{deformation}\phantom{\rule{0.28em}{0ex}}(\ensuremath{\beta}$)-constraint antisymmetrized molecular dynamics combined with the generator coordinate method. A low-energy $E1$ mode, which is caused surface neutron oscillation along prolate deformation was obtained as ${1}_{2}^{\...