نتایج جستجو برای: null genotype

تعداد نتایج: 136240  

ژورنال: مجله دانشگاه علوم پزشکی شهید صدوقی یزد 2012
حقیرالسادات , بی بی فاطمه , دهقانی, مصطفی , شرف دینی, مریم, شیخها, محمد حسن, معین, محمدرضا, وحیدی, علیرضا,

Introduction: GSTM and GSTT are subclasses of glutathione s-transferase that is present on human sperm surface and plays an important role against oxidative stress. This study aimed to investigate the polymorphisms of GSTT1 and GSTM1 in regard to sperm parameters. Methods: This case-control study involved 46 men with varicocele and 48 men without varicocele. Semen analyses were carried out ac...

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Journal: :iranian journal of immunology 0
mohammad hasan sheikhha genetic department, clinical and research center for infertility, shahid sadughi university of medical sciences, yazd, iran mehdi kalantar genetic department, clinical and research center for infertility, shahid sadughi university of medical sciences, yazd, iran khalid tobai mrd lab, king’s college, london, uk. john a. liu yin department of haematology, manchester royal infirmary, manchester, uk.

background: the glutathione s-transferase (gst) family of metabolising enzymes plays an important role in the detoxification of mutagens and carcinogens. the expression of many of these cancer susceptibility enzymes is genetically polymorphic. an increased frequency of gst-null genotypes has been associated with several malignancies. objective: to investigate the rate of gstt1 and gstm1 null ge...

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Journal: :international journal of reproductive biomedicine 0
seyed morteza seifati kazem parivar abbas aflatoonian razieh dehghani firouzabadi mohammad hasan sheikhha

background: endometriosis is one of the most common gynecologic disorders. it is a complex trait and both genetic and environmental factors have been implicated in its pathogenesis. there is growing evidence indicating that exposure to environmental contaminants is a risk factor for endometriosis. glutathione-s-transferase m1 (gstm1) is one of the genes involved in detoxification of endogenous ...

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ژورنال: مجله دانشگاه علوم پزشکی مازندران 2014
آهنگر, نعمت الله, شکرزاده, محمد , علیدادی, حدیث ,

Background and purpose: Glutathion S-transferase (GSTs) are a family of detoxification phase II enzymes that catalyze the conjugation of carcinogenic and cytotoxic componds with glutathion. GSTs are polymorphic and deletion of GSTM1 and GSTT1 polymorphism is caused by lack of enzyme production that lead to loss of antioxidant activity. In this study, we examined the frequency of GSTM1 and G...

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ژورنال: مجله پزشکی ارومیه 2016
صفی نژاد, کیومرث,

Background & Aims: Recurrent Pregnancy Loss (RPL) is defined as two or more consecutive spontaneous abortions. Glutathione S-transferase genes produce isoenzymes that protect embryo against oxidative stress. The aim of this study was to determine the removal of the two genes, GSTT1 and GSTM1 in male partners of couples having RPL. Materials & Methods: A case-control study of 102 cases w...

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Journal: :iranian journal of public health 0
saeedeh salimi cellular and molecular research center, zahedan university of medical sciences, zahedan, iran and dept. of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, iran. alireza nakhaee cellular and molecular research center, zahedan university of medical sciences, zahedan, iran and dept. of clinical biochemistry, school of medicine, zahedan university of medical sciences, zahedan, iran. mehdi jafari cellular and molecular research center, zahedan university of medical sciences, zahedan, iran. danial jahantigh dept. of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, iran. mahnaz sandooghi dept. of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, iran. zahra zakeri dept. of internal medicine, school of medicine, zahedan university of medical sciences, zahedan, iran.

background : progression of systemic lupus erythematosus (sle) could be due to oxidative stress especially through reactive oxygen species (ros). detoxification of ros is largely performed by glutathione s-transferases (gsts), therefore polymorphisms of gstm1, gstt1 and gstp1 genes which decrease enzymes activity could affect sle susceptibility. the aim of this study was to determine the effect...

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Journal: :middle east journal of cancer 0
ait boujmia oum kaltoum laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco nadifi sellama laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco dehbi hind laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco kassogue yaya laboratory of genetics and molecular pathology, medical school, university hassan ii, casablanca, morocco lamchahab mouna department of onco-hematology, ibn rochd university hospital, casablanca, morocco quessar asma department of onco-hematology, ibn rochd university hospital, casablanca, morocco

background: acute myeloid leukemia, as most cancers, results from exposure to carcinogens and an impaired inherited individual capacity to eliminate xenobiotics. the present case-control study measures the relationship between glutathione s-transferase (gst) t1 and m1 null genotypes and the risk of acute myeloid leukemia. methods: we identified the gstt1 andgstm1 genotypes by multiplex polymera...

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Journal: Iranian Biomedical Journal 2001
Iraj Saadat, Mostafa Saadat, Shahpour Omidvari,

Glutathione S-transferases (GSTs) are encoded by a superfamily of genes and play a role in the detoxification of potential carcinogens. The human GSTs are divided into four classes: alpha, mu, pi and theta. Previous studies indicated that the absence of the Glutathione S-Transferase M1 (GSTM1) protein correlated with an increased risk of developing some types of cancers. Association between spe...

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Journal: :iranian journal of public health 0
mohammadhosain afrand medical scientific association, ali-ebne abitaleb faculty of medicine, islamic azad university, yazd branch, yazd, iran. nasrollah bashardoost dept. of biostatistics and epidemiology, ali-ebne abitaleb faculty of medicine, islamic azad university, yazd branch, yazd, iran. mohammad hasan sheikhha dept. of medical genetics, yazd diabetes research center, shahid sadoughi university of medical sciences, yazd, iran. mohammad afkhami-ardekani dept. of endocrinology, yazd diabetes research center, shahid sadoughi university of medical sciences, yazd, iran.

the aim of this study was to assess the possible association between genetic polymorphisms of the glutathione s-transferase (gst) gene family and the risk of the development of metabolic syndrome (ms) in zoroastrian females in yazd, iran.in this case-control study, gstm1, t1, and p1 polymorphisms were genotyped in 51 randomly selected ms patients and 50 randomly selected healthy controls on feb...

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ژورنال: مجله دانشکده پزشکی دانشگاه علوم پزشکی تهران 2009
آخوندی, محمد مهدی, حجت, مهشید, صادقی, محمدرضا, فریور, شیرین, مدرسی, محمد حسین, میرفیض‌‌اللهی, آزاده,

Background: Pi-GST and Mu-GST are subclasses of glutathione S-transferase that present on human sperm surface and play an important role against oxidative stress. Therefore, any defects in the enzyme activity may be associated with male infertility.In this study the polymorphisms of GSTM1 and GSTP1 in association with enzyme activity and sperm parameters were studied. Methods: This case-contro...

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