نتایج جستجو برای: nucleoside
تعداد نتایج: 14337 فیلتر نتایج به سال:
abstract background and objective: highly active antiretroviral therapy (haart) can effectively prevent the progression of hiv-1 replication and increase life expectancy. there are numerous causes of treatment failure and the leading one is drug resistance. thus, we aimed to determine the hiv rt gene drug resistance mutations in patients treated with antiretroviral medications. material and met...
Abstract Background and Objective: Highly Active Antiretroviral Therapy (HAART) can effectively prevent the progression of HIV-1 replication and increase life expectancy. There are numerous causes of treatment failure and the leading one is drug resistance. Thus, we aimed to determine the HIV RT gene drug resistance mutations in patients treated with antiretroviral medications. Material...
Abstract Background and Objective: Resistance to antiretroviral agents is a significant concern in clinical management of HIV-infected individuals. Resistance is the result of mutations that develops in the viral protein targeted by antiretroviral agents. Material and Methods: In this cross-sectional study, the blood samples of 40 HIV-positive patients were collected. Twenty of them were d...
background tenofovir disoproxil fumarate (tdf) is a new effective treatment option for patients with chronic hepatitis b (chb). objectives to evaluate tdf efficacy in nucleos(t)ide analogues (nas)-naive iranian patients with chb. patients and methods the na-naive patients received tdf for at least six months. the primary endpoint was the proportion of patients achieving a complete virological r...
Front Cover. A new C-nucleoside with strongly pairing ethynylmethylpyridone base and 3'-azido-2',3'-dideoxyribose sugar dubbed 'AZW' was described. The image shows the structure of AZW against a backdrop AZT in dotted cloud representation. nucleoside inhibitory activity Herpes simplex virus type 1 (HSV1) as reported by Richert et al. their full paper at10.1002/cbdv.202000937.
it is important to determine whether a candidate molecule is capable of penetrating the plasma-brain barrier indrug discovery and development. the aim of this paper is to establish a predictive model for plasma-brainbarrier penetration using simple descriptors the usefulness of the quantum chemical descriptors, calculated atthe level of the dft and he theories using 6-310* basis set for qsar st...
Understanding and optimization of the photophysics fluorescent nucleoside analogues are critical for their applications in probing structure dynamics nucleic acids, studying interactions with ligands biomolecules.
In this study the uptake and metabolism of adenosine by mitochondria has been investigated. Incubation of CEM cells mitochondria preparation with [3H] -adenosine showed substantial uptake and metabolism of adenosine. Adenosine was both anabolized to AMP, ADP and ATP, and also catabolized to inosine. The highest concentration of metabolites in extracted mitochondria was due to AMP. The mito...
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