purpose: to evaluate the safety of different doses of intravitreal bevacizumab in rabbit eyes. methods: twelve eyes of 6 rabbits underwent intravitreal injection of 5, 7.5 and 10 mg of bevacizumab. in each rabbit, one eye was considered for bevacizumab injection and the fellow eye served for either placebo injection or observation. all eyes were examined before and 1, 2, 3, 7, 14 and 28 days af...

Aim: Several ocular and systemic complications have been reported after the bevacizumab intravitreal injection. This study aims at reporting the main indications for the bevacizumab intravitreal injection in our center, the intravitreal injection method in this study, and the incidence of the post-injection complication, such as endophthalmitis.Methods: This study is a retrospective review of t...

Abstract: Title: Teratogenic Effects of Intravitreal Injection of Bevacizumab in Pregnant Rat Models Aim: To investigate teratogenic effect of intravitreal injection of bevacizumab in pregnant rat model Methods: Twenty seven female Wistar rat were inseminated. Pregnant rats were divided into 6 groups (three groups as case and three as control groups). Each case and control groups divided accord...

Background: Cystoid Macular Edema (CME) is one of the most common and sight threatening complications of uveitis. Intravitreal injection of corticosteroids and anti-VEGF antibody are two routine options for treatment. Objective: To compare the effects of intravitreal injections of Bevacizumab and Triamcinolone Acetonide for the treatment of persistent macular edema in non-infectious uveitis. Me...

Aim: Several ocular and systemic complications have been reported after the bevacizumab intravitreal injection. This study aims at reporting the main indications for the bevacizumab intravitreal injection in our center, the intravitreal injection method in this study, and the incidence of the post-injection complication, such as endophthalmitis.Methods: This study is a retrospective review of t...

Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment models sometimes failed to appropriately describe those properties. In this work, a new model was built on a comprehensive analysis of the complex elimination of mAbs. This new model was firstly utilized to fit with the single-dose plasma concent...

Complex pharmacokinetic (PK) properties including nonlinear elimination were encountered by some monoclonal antibodies (mAbs), and classic compartment models sometimes failed to appropriately describe those properties. In this work, a new model was built on a comprehensive analysis of the complex elimination of mAbs. This new model was firstly utilized to fit with the single-dose plasma concent...

dear editor:   bevacizumab is monoclonal antibody approved by the us fda for metastatic colorectal cancer.1 off-label intravitreal bevacizumab is gaining popularity among ophthalmologists worldwide, due to its reported efficacy. we are using intravitreal injections of bevacizumab prepared in single dosage form (while maintaining sterility) for the treatment of choroidal neovascularization, prol...

purpose: to report an idiopathic retinal vasculitis, aneurysm, neuroretinitis (irvan) case treated with one session of panretinal photocoagulation (prp) and intravitreal bevacizumab (avastin) case report: a 13-year-old boy was diagnosed as an irvan syndrome. systemic examination, fundus angiography, brain mri were performed to evaluate the patient. treatment with one session of prp, retinopexy ...

We report a 64-year-old diabetic woman who developed neovascularization of the posterior capsule 2 years after cataract surgery and intraocular lens implantation. The patient was treated with single injection of 1.25 mg of intravitreal bevacizumab (Avastin) via pars plana. After one week, complete regression of the posterior capsule neovascularization was achieved allowing us to perform Nd: YAG...