نتایج جستجو برای: ns1

تعداد نتایج: 2089  

پایان نامه :وزارت علوم، تحقیقات و فناوری - دانشگاه شهید چمران اهواز - دانشکده دامپزشکی 1389

ویروس آنفولانزای مرغی از جنس آنفولانزا ویروس a و از خانواده ارتومیکسوویریده می باشد . هدف از این تحقیق کلون کردن و تعیین توالی ژن کد کننده پروتئین ns1 از یک جدایه ی بومی ویروس آنفولانزای مرغی تحت تیپ h9n2 بود. پروتئین ns1 جهت طراحی تست الیزا، برای تفریق طیور عفونی از طیور واکسینه شده، استفاده می شود. بدین منظور ابتدا براساس چندین توالی نوکلئوتیدی ns1، از ویروس آنفولانزای مرغی h9n2 که از منابع ا...

Journal: :Biochemical and biophysical research communications 2013
Masaya Miyazaki Hiroshi Nishihara Hideki Hasegawa Masato Tashiro Lei Wang Taichi Kimura Mishie Tanino Masumi Tsuda Shinya Tanaka

The influenza A virus non-structural protein 1 (NS1) is a multifunctional virulence factor consisting of an RNA binding domain and several Src-homology (SH) 2 and SH3 binding motifs, which promotes virus replication in the host cell and helps to evade antiviral immunity. NS1 modulates general host cell physiology in association with various cellular molecules including NS1-binding protein (NS1-...

Journal: :Genes & development 1992
F V Alonso-Caplen M E Nemeroff Y Qiu R M Krug

Influenza virus unspliced NS1 mRNA, like retroviral pre-mRNAs, is efficiently exported from the nucleus and translated in the cytoplasm of infected cells. With human immunodeficiency virus (HIV), the transport of viral pre-mRNAs is facilitated by the viral Rev protein. We tested the possibility that the influenza virus NS1 protein, a nuclear protein that is encoded by unspliced NS1 mRNA, has th...

2015
Yuki Takamatsu Muhareva Raekiansyah Kouichi Morita Daisuke Hayasaka

Using a mouse model, we previously demonstrated that subcutaneous infection with the JaTH160 strain of Japanese encephalitis virus (JEV) causes significantly higher virulence and stronger virus propagation in the brain compared with that of the JaOArS982 strain. We also showed that the JaTH160 strain, but not JaOArS982, expresses the NS1' protein and that NS1' enhances JEV production in avian c...

2014
Shu-Wen Wan Yi-Tien Lu Chia-Hui Huang Chiou-Feng Lin Robert Anderson Hsiao-Sheng Liu Trai-Ming Yeh Yu-Ting Yen Betty A. Wu-Hsieh Yee-Shin Lin

BACKGROUND Infection with dengue virus (DENV) may cause life-threatening disease with thrombocytopenia and vascular leakage which are related to dysfunction of platelets and endothelial cells. We previously showed that antibodies (Abs) against DENV nonstructural protein 1 (NS1) cross-react with human platelets and endothelial cells, leading to functional disturbances. Based on sequence homology...

Journal: :The Journal of general virology 1997
F F Maree H Huismans

The characteristic tubules that are produced during the orbivirus infection cycle are composed of a major viral nonstructural protein, NS1. To characterize the NS1 gene and gene product of African horsesickness virus (AHSV), a full-length cDNA copy of the NS1 gene of AHSV-6 was cloned and the nucleotide sequence determined. NS1 was highly conserved within the AHSV serogroup with between 95-98% ...

Journal: :The Journal of biological chemistry 2011
Denis E Kainov Konstantin H Müller Linda L Theisen Maria Anastasina Minttu Kaloinen Claude P Muller

The nonstructural protein NS1 of influenza A virus blocks the development of host antiviral responses by inhibiting polyadenylation of cellular pre-mRNA. NS1 also promotes the synthesis of viral proteins by stimulating mRNA translation. Here, we show that recombinant NS1 proteins of human pandemic H1N1/2009, avian highly pathogenic H5N1, and low pathogenic H5N2 influenza strains differentially ...

2011
Jia Yu Xin Li Yu Wang Bo Li Hongyue Li Yapeng Li Weihong Zhou Cuizhu Zhang Yingying Wang Zihe Rao Mark Bartlam Youjia Cao

The multi-functional NS1 protein of influenza A virus is a viral virulence determining factor. The last four residues at the C-terminus of NS1 constitute a type I PDZ domain binding motif (PBM). Avian influenza viruses currently in circulation carry an NS1 PBM with consensus sequence ESEV, whereas human influenza viruses bear an NS1 PBM with consensus sequence RSKV or RSEV. The PBM sequence of ...

Journal: :Journal of virology 2013
Andres Santos Sangita Pal Jason Chacón Katherine Meraz Jeanette Gonzalez Karla Prieto Germán Rosas-Acosta

Our pioneering studies on the interplay between the small ubiquitin-like modifier (SUMO) and influenza A virus identified the nonstructural protein NS1 as the first known SUMO target of influenza virus and one of the most abundantly SUMOylated influenza virus proteins. Here, we further characterize the role of SUMOylation for the A/Puerto Rico/8/1934 (PR8) NS1 protein, demonstrating that NS1 is...

Journal: :Journal of virology 2009
Venkatramana D Krishna Manjuladevi Rangappa Vijaya Satchidanandam

We demonstrate the presence of nonstructural protein 1 (NS1)-specific antibodies in a significant proportion of convalescent-phase human serum samples obtained from a cohort in an area where Japanese encephalitis virus (JEV) is endemic. Sera containing antibodies to NS1 but not those with antibodies to other JEV proteins, such as envelope, brought about complement-mediated lysis of JEV-infected...

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