نتایج جستجو برای: nrf

تعداد نتایج: 1068  

Journal: :The EMBO journal 1998
J Y Chan M Kwong R Lu J Chang B Wang T S Yen Y W Kan

The CNC-basic leucine zipper (CNC-bZIP) family is a subfamily of bZIP proteins identified from independent searches for factors that bind the AP-1-like cis-elements in the beta-globin locus control region. Three members, p45-Nf-e2, Nrf-1 and Nrf-2 have been identified in mammals. Expression of p45-Nf-e2 is largely restricted to hematopoietic cells while Nrf-1 and Nrf-2 are expressed in a wide r...

Journal: :The European respiratory journal 2012
Kang-Yun Lee Shu-Chuan Ho Yao-Fei Chan Chun-Hua Wang Chien-Da Huang Wen-Te Liu Shu-Min Lin Yu-Lun Lo Ya-Ling Chang Lu-Wei Kuo Han-Pin Kuo

Chronic systemic inflammation is implicated in the systemic manifestations and, probably, the excess mortality risk of chronic obstructive pulmonary disease (COPD). The role of nuclear factor (NF)-κB repressing factor (NRF), a DNA-binding, protein-inhibiting NF-κB response gene, in human diseases has not been explored. We hypothesised that the NRF-negative regulatory mechanism is impaired in CO...

Journal: :The Journal of biological chemistry 2009
Mohammad B Hossain Ping Ji Ramakrishnan Anish Raymond H Jacobson Shinako Takada

Nuclear respiratory factor 1 (NRF-1) is one of the key transcriptional activators for nuclear-coded genes involved in mitochondrial biogenesis and function as well as for many housekeeping genes. A transcriptional co-activator PGC-1 and its related family member PRC have previously been shown to interact with NRF-1 and co-activate NRF-1. We show here that NRF-1 can also directly interact with p...

Journal: :The Journal of biological chemistry 2010
Nitzan Gonen Yehuda G Assaraf

Folates are essential vitamins that play a key role as one-carbon donors in a spectrum of biosynthetic pathways including RNA and DNA synthesis. The proton-coupled folate transporter (PCFT/SLC46A1) mediates obligatory intestinal folate absorption. Loss-of-function mutations in PCFT result in hereditary folate malabsorption, an autosomal recessive disorder characterized by very low folate levels...

Journal: :FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003
Keith Baar Zheng Song Clay F Semenkovich Terry E Jones Dong-Ho Han Lorraine A Nolte Edward O Ojuka May Chen John O Holloszy

Nuclear respiratory factor 1 (NRF-1) is a transcriptional activator of nuclear genes that encode a range of mitochondrial proteins including cytochrome c, various other respiratory chain subunits, and delta-aminolevulinate synthase. Activation of NRF-1 in fibroblasts has been shown to induce increases in cytochrome c expression and mitochondrial respiratory capacity. To further evaluate the rol...

2013
Kuo-Hsiung Huang Chun-Hua Wang Kang-Yun Lee Shu-Min Lin Chien-Huang Lin Han-Pin Kuo

NF-κB repressing factor (NRF) is a transcriptional silencer implicated in the basal silencing of specific NF-κB targeting genes, including iNOS, IFN-β and IL-8/CXCL8. IP-10/CXCL10 and IL-8/CXCL8 are involved in neutrophil and lymphocyte recruitment against M. tuberculosis (MTb) and disease progression of pulmonary tuberculosis (TB). Alveolar macrophages (AM) and peripheral blood mononuclear cel...

Journal: :Blood 1998
F Martin J M van Deursen R A Shivdasani C W Jackson A G Troutman P A Ney

NF-E2 binding sites, located in distant regulatory sequences, may be important for high level alpha- and beta-globin gene expression. Surprisingly, targeted disruption of each subunit of NF-E2 has either little or no effect on erythroid maturation in mice. For p18 NF-E2, this lack of effect is due, at least in part, to the presence of redundant proteins. For p45 NF-E2, one possibility is that N...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2002
Xuesheng Feng Zhong Guo Mahtab Nourbakhsh Hansjorg Hauser Ray Ganster Lifang Shao David A Geller

Although nuclear factor (NF)-kappaB plays a central role in mediating cytokine-stimulated human inducible nitric-oxide synthase (hiNOS) gene transcription, very little is known about the factors involved in silencing of the hiNOS promoter. NF-kappaB-repressing factor (NRF) interacts with a specific negative regulatory element (NRE) to mediate transcriptional repression of certain NF-kappaB resp...

Journal: :Molecular and cellular neurosciences 2014
Ann-Christin Cichon David R Brown

Cellular expression of host prion protein (PrP) is essential to infection with prion disease. Understanding the mechanisms that regulate prion protein expression at both the transcriptional and translational levels is therefore an important goal. The cellular prion protein has been associated with resistance to oxidative, and its expression is also increased by oxidative stress. The transcripti...

Journal: :Toxicological sciences : an official journal of the Society of Toxicology 2004
Jason M Hansen Walter H Watson Dean P Jones

Nrf-2 is a redox-sensitive transcription factor that is activated by an oxidative signal in the cytoplasm but has a critical cysteine that must be reduced to bind to DNA in the nucleus. The glutathione (GSH) and thioredoxin (TRX) systems have overlapping functions in thiol/disulfide redox control in both the cytoplasm and the nucleus, and it is unclear whether these are redundant or have unique...

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