the objective of the present study was to determine whether there was an association between the in vitroantimicrobial sensitivity test results of subclinical mastitis pathogensand bacteriological cure following intramammary treatment using a combination of nafcillin, penicillin, and streptomycin (nps). eighty-six intramammary pathogens from 43 cows were examined inthis study. most intramammary...

background: sensitive and glucantime (ma) resistance leishmania tropica are referred to those isolates, which are responsive, or non-responsive to one or two full courses of treatment by ma systematically and/or intra-lesionally, respectively. in this study, we evaluated the antileishmanial activity of biogenic selenium nanoparticles (se nps) alone and in combination with ma against sensitive a...

Objective(s): Photo-thermal therapy (PTT) is a therapeutic method in which photon energy is converted into heat to induce hyperthermia in malignant tumor cells. In this method, energy conversion is performed by nanoparticles (NPs) to enhance induced heat efficacy. The low-cytotoxicity and high optical absorbance of NPs used in this technique are very important. In the present study, titanium di...

The treatment of glioblastoma (GBM) is a challenge for the biomedical research since cures remain elusive. Its current therapy, consisted on surgery, radiotherapy, and concomitant chemotherapy with temozolomide (TMZ), is often uneffective. Here, we proposed the use of zoledronic acid (ZOL) as a potential agent for the treatment of GBM. Our group previously developed self-assembling nanoparticle...

Caffeine has marked effects on sleep, arousal and food intake. However, the neuronal mechanisms underlying these actions are not fully understood. Neuropeptide S (NPS) is a recently discovered neuropeptide regulating both sleep and feeding. Here, we examined the effect of acute and chronic caffeine treatment on the expression of neuropeptide S and its receptor (NPS-R) in the hypothalamus and br...

this study aimed to investigate the effects of tow nanoparticles (nps) on the absorption,accumulation, reproduction of the eisenia fetida. a 4×2×2 factorial experiment in a randomized completeblock design with three replications was conducted. the factors included in the experiment are the content ofnps at four levels (0, 0.4, 0.8, and 1.2gr/kg weight of substrate), the type of nps at two level...

the biological application of nanoparticles (nps) is a rapidly developing area of nanotechnology that raises new possibilities in the treatment of human cancers. the cytotoxicity was evaluated by mtt and ldh assays. the apoptotic effect of free icd-85 and icd-85 nps on hela cells was assessed using caspase-8 colorimetric assay. the mtt assay showed that icd-85 nps could enhance the in-vitro cyt...

Sustainable and safe delivery of brain-targeted drugs is highly important for successful therapy in Parkinson's disease (PD). This study was designed to formulate biodegradable poly(ethylene glycol)-poly(lactic-co-glycolic acid) (PEG-PLGA) nanoparticles (NPs), which were surface-modified with lactoferrin (Lf), for efficient intranasal delivery of rotigotine to the brain for the treatment of PD....

The objective of the present study was to determine whether there was an association between the in vitroantimicrobial sensitivity test results of subclinical mastitis pathogensand bacteriological cure following intramammary treatment using a combination of nafcillin, penicillin, and streptomycin (NPS). Eighty-six intramammary pathogens from 43 cows were examined inthis study. Most intramammary...

Background: The application of nano-particles (NPs) in various industries is growing. Since their toxicity is not clearly understood, they can cause adverse effects on the environment. The aim of this study was to evaluate the histopathological effects of iron oxide nano-particles on the small intestine of common carp, Cyprinus carpio. Methods: Four experimental treatments were designed (15 ...