OBJECTIVES Takayasu arteritis (TAK) is a large-vessel vasculitis of unknown aetiology. The annual incidence in hospital-based studies is 1-2/million. The UK General Practice Research Database (UKGPRD) contains complete primary care records on 3.6 million people. There are no data on the incidence of TAK in the UK or from primary care anywhere in the world. The aim of this study was to determine...

Methods: The use of LLT for patients with CAD was prospectively evaluated in 825 men and women who were recruited from 16 academic medical centers in the United States and Canada to participate in the Prospective Evaluation of the Vascular Events of Norvasc Trial (PREVENT). The assessment of LLT use during the 3-year trial was evaluated in patients receiving amlodipine therapy and placebo; leve...

background: the efficacy of amlodipine, a calcium channel blocker, in treating systemic hypertension is well established but the most efficacious brand of this drug is still uncertain. the cost of different brands of amlodipine is tremendously different which may affect decision-making in hypertension treatment. the purpose of this study was to compare the efficacy and safety of different brand...

Sir, Side-e¡ects of drugs are often thought to be the cause of certain skin manifestations, especially in cases of clear time-relationships. We describe here a patient in whom side-e¡ects of antihypertensive drugs were suspected, but since the speci¢c combination of telangiectasia of the cheeks and gingival hyperplasia had not been described previously some delay occurred before it was clear th...

BACKGROUND We have shown previously that some calcium antagonists inhibit hyaluronan export, loss of proteoglycans, and degradation of collagen from osteoarthritic cartilage. Clinically approved calcium antagonists normally are prescribed for cardiac arrhythmia. In the present study, we compared the effect of these drugs on osteoarthritic patients which had received no medication and patients w...

Oct 28, 2011. There was no significant difference between groups in the incidence of. These results demonstrate that combination amlodipine/losartan . amlodipine 5 mg once daily or losartan 50 mg once at the end of treatment, with no difference between mild to moderate hypertension was defined as the. 3 Answers Posted in: high blood pressure, amlodipine, losartan Answer: I. They both have diffe...

To the Editor: The Prospective Randomized Evaluation of the Vascular Effects of Norvasc Trial (PREVENT)1 amplifies the controversy over calcium antagonists and increased cancer risk.2 In this 36-month, placebo-controlled, randomized trial, the calcium antagonist amlodipine had no effect on the angiographic progression of coronary atherosclerosis or on the risk of major cardiovascular events. In...

A man in his sixties was admitted to hospital late one evening after fainting in the bathroom. He had felt increasingly lethargic in the days immediately prior to hospitalisation, but had not otherwise noticed anything out of the ordinary. He had been treated for hypertension for the past 10 – 12 years, initially with amlodipine (Norvasc), subsequently with carvediol, irbesartan/hydrochlorothia...