We demonstrated the effect of nortriptyline, a tricyclic antidepressant drug and serotonin reuptake inhibitor, on voltage-dependent K+ (Kv) channels in freshly isolated rabbit coronary arterial smooth muscle cells using a whole-cell patch clamp technique. Nortriptyline inhibited Kv currents in a concentration-dependent manner, with an apparent IC50 value of 2.86±0.52 µM and a Hill coefficient o...

OBJECTIVE To test the efficacy of nortriptyline plus nicotine replacement therapy compared with placebo plus nicotine replacement therapy for smoking cessation. DESIGN Pragmatic randomised controlled trial. SETTING National Health Service stop smoking service clinics. PARTICIPANTS 901 people trying to stop smoking. INTERVENTIONS Participants chose their nicotine replacement product, inc...

background: the negative symptoms of schizophrenia remain a major clinical challenge. nortriptyline is a serotonin and noradrenalin reuptake inhibitor and belongs to secondary amine tricycles. the aim of this study is to evaluate the effect of nortriptyline on the negative symptoms of schizophrenia.   methods: this study is a six-week randomized placebo-control trial of nortriptyline or placebo...

CONTEXT Electroconvulsive therapy (ECT) is highly effective for treatment of major depression, but naturalistic studies show a high rate of relapse after discontinuation of ECT. OBJECTIVE To determine the efficacy of continuation pharmacotherapy with nortriptyline hydrochloride or combination nortriptyline and lithium carbonate in preventing post-ECT relapse. DESIGN Randomized, double-blind...

Corticosteroid insensitivity represents a major barrier to the treatment of chronic obstructive pulmonary disease (COPD) and severe asthma. It is caused by oxidative stress, leading to reduced histone deacetylase-2 (HDAC2) function through activation of phosphoinositide-3-kinase-δ (PI3Kδ). The tricyclic antidepressant nortriptyline has been identified in high-throughput screens as an agent that...

BACKGROUND AND PURPOSE Nortriptyline, an antidepressant, was identified as a strong inhibitor of mitochondrial permeability transition by our screening of a library of 1040 drugs. Because mitochondrial permeability transition and consequent mitochondrial dysfunction have been implicated in acute neuronal death, we proposed to investigate the possible neuroprotective effects of nortriptyline in ...

Gabapentin and Nortriptyline are used to treat neuropathic pain. belongs a group of drugs called anti-convulsant tricyclic antidepressant. acts by binding the specific site on voltage- gated calcium channels. This helps in relieving nerve pain lowers risk seizure. works preventing released chemical messengers brain (serotonin norepinephrine) from being reabsorbed back into cells. As result, it ...

Nortriptyline derivatives prepared by reaction with fluorescein isothiocyanate or conjugation to N-acetyl-L-histidine were radioiodinated and the products purified with Sephadex LH-20 columns to obtain two novel nortriptyline radioligands. Antisera were raised in rabbits by immunization with nortriptyline conjugated to succinylated ovine albumin. By use of the iodinated fluorescein derivative w...

CONTEXT Elderly patients with major depression are at high risk for recurrence, increased mortality, and chronic disability. OBJECTIVE To determine the efficacy of maintenance nortriptyline hydrochloride and interpersonal psychotherapy (IPT) in preventing recurrence of major depressive episodes in patients older than 59 years. DESIGN A 2 x 2 randomized, double-blind, placebo-controlled clin...