Beta-thalassemia is one of the most common autosomal recessive disorders in the world population resulting from over 200 different mutations of HBB gene. Beta-thalassemias are caused by point mutations or, more rarely, deletions in the HBB gene leading to reduced (beta+) or absent (beta0) synthesis of the beta chains of hemoglobin (Hb). High-resolution melting of polymerase chain reaction (PCR)...

Supplementary Material 1. Supplementary Figure Titles Supplementary Figure 1: Quantile-Quantile (QQ) plot of the discovery phase metaanalysis of RR-interval among the European-ancestry individuals. Supplementary Figure 2: (a) Comparison of the betas between the untransformed RR-interval meta-analysis and the inverse normalized RR-interval residuals (RR-INVN) meta-analysis; (b) Comparison of the...

Parameterization of the glottal flow is a process where the glottal flow is represented in terms of a few numerical values. This study proposes a novel parameterization technique called the phase plane symmetry (PPS) parameter that utilizes the symmetrical properties of the phase plane plot. Phase plane is a way to graphically visualize the glottal source in a 2-dimensional space spanned by two...

The Jasper Fire occurred in the Black Hills National Forest, South Dakota, during August and September of 2000. The fire disturbance to ecosystem characteristics was widespread and long-term. The goal of this study is to examine the correlations between spectral indices and field-observed burn severity, and to provide a practical method to estimate burn severity using remote sensing data. We us...

The purpose of this investigation was to determine if phase plot normalization and phase angle definitions would have an affect on continuous relative phase calculations. A subject ran on a treadmill while sagittal plane kinematic data were collected with a high-speed (180 Hz) camera. Segmental angular displacements and velocities were used to create phase plots, and examine the coordination be...

PURPOSE To process single voxel spectra of low- and high-grade gliomas. To propose correlation analysis of the scatter plots of normalized spectral amplitudes as a pattern recognition tool for the classification (grading) of brain tumors. To propose a spectrum processing approach that improves the differentiation of proton spectra with dominating macromolecule and lipid peaks. MATERIALS AND M...

In the main text, we noted that the shape parameters (characteristic length, Λ, and loop radius, Ro) of the patterns only depend weakly on the deployment height. To resolve this height dependence of the pattern length scales, we have performed a series of numerical simulations where we have varied the normalized deployment height, H̄, while keeping the gravito-bending length fixed at Lgb = 3.3 c...

The continuous wavelet transform may be enhanced by deconvolution with the wavelet response function. After correcting for the coneof-influence, the power spectral density of the solar magnetic record as given by the derectified yearly sunspot number is calculated, revealing a spectrum of odd harmonics of the fundamental Hale cycle, and the integrated instant power is compared to a reconstructi...

In the usual forms of homogeneity analysis (which are also known as multiple correspondence analysis or MCA) the size of a point set is defined as the size of the star plot of the set. The star plot is the graph defined by connecting all points in the set with their centroid, and the size is the total squared length of the edges. In order to prevent trivial solutions the configuration X is usua...