نتایج جستجو برای: nor1

تعداد نتایج: 96  

Journal: :Circulation research 2010
Yue Zhao Deborah A Howatt Florence Gizard Takashi Nomiyama Hannes M Findeisen Elizabeth B Heywood Karrie L Jones Orla M Conneely Alan Daugherty Dennis Bruemmer

RATIONALE The orphan nuclear receptor NOR1 is a member of the evolutionary highly conserved and ligand-independent NR4A subfamily of the nuclear hormone receptor superfamily. Members of this subfamily have been characterized as early response genes regulating essential biological processes including inflammation and proliferation; however, the role of NOR1 in atherosclerosis remains unknown. ...

Journal: :Acta biochimica et biophysica Sinica 2009
Bo Xiang Mei Yi Li Wang Wei Liu Wenling Zhang Jue Ouyang Ya Peng Wenjuan Li Dachuan Yin Ming Zhou Huaying Liu Minghua Wu Rong Wang Xiaoling Li Guiyuan Li

Oxidored-nitro domain containing protein 1 (NOR1) gene is a novel nitroreductase gene first isolated from nasopharyngeal carcinoma (NPC). It plays an important role in the formation of chemical carcinogen and the carcinogenesis of NPC for its nitrosation function. Overexpression of the wild-type NOR1 gene in nasopharyngeal carcinoma cells is effective to inhibit cell growth and proliferation. I...

Journal: :Circulation 2009
Takashi Nomiyama Yue Zhao Florence Gizard Hannes M Findeisen Elizabeth B Heywood Karrie L Jones Orla M Conneely Dennis Bruemmer

BACKGROUND The neuron-derived orphan receptor-1 (NOR1) belongs to the evolutionary highly conserved and most ancient NR4A subfamily of the nuclear hormone receptor superfamily. Members of this subfamily function as early-response genes regulating key cellular processes, including proliferation, differentiation, and survival. Although NOR1 has previously been demonstrated to be required for smoo...

2017
Mei Yi Jianbo Yang Wenjuan Li Xiaoling Li Wei Xiong James B. McCarthy Guiyuan Li Bo Xiang

NOR1 (Oxidored-nitro domain-containing protein 1), also known as OSCP1, was first identified in nasopharyngeal carcinoma (NPC) cells in 2003. NOR1 is evolutionarily conserved among species with its expression is restricted to brain, testis and respiratory epithelial cells. NOR1 was downregulated in NPC and the downregulation associates with poor prognosis. Previous study demonstrated that hyper...

Journal: :Oncology reports 2013
Jue Ouyang Minghua Wu Chen Huang Li Cao Guiyuan Li

Oxidored-nitro domain containing protein 1 (NOR1) is a novel member of the nitroreductase family that was first isolated as a tumor suppressor gene from human nasopharyngeal carcinoma (NPC). However, the role of NOR1 gene dysfunction in human cancers has not been addressed. We analyzed the expression of NOR1 in various human cancer and benign tiss...

2017
Hua Qing Karrie L Jones Elizabeth B Heywood Hong Lu Alan Daugherty Dennis Bruemmer

BACKGROUND The NR4A3 orphan nuclear hormone receptor, NOR1, functions as a constitutively active transcription factor to regulate inflammation, proliferation, and cell survival during pathological vascular remodeling. Inflammatory processes represent key mechanisms leading to abdominal aortic aneurysm (AAA) formation. However, a role of NOR1 in AAA formation has not been investigated previously...

Journal: :International journal of systematic and evolutionary microbiology 2004
Tatyana G Sokolova Juan M González Nadezhda A Kostrikina Nikolai A Chernyh Tatiana V Slepova Elizaveta A Bonch-Osmolovskaya Frank T Robb

A new anaerobic, thermophilic, facultatively carboxydotrophic bacterium, strain Nor1(T), was isolated from a hot spring at Norris Basin, Yellowstone National Park. Cells of strain Nor1(T) were curved motile rods with a length of 2.6-3 microm, a width of about 0.5 microm and lateral flagellation. The cell wall structure was of the Gram-negative type. Strain Nor1(T) was thermophilic (temperature ...

Journal: :Carcinogenesis 2011
Wenjuan Li Xiaoling Li Wei Wang Xiayu Li Yixin Tan Mei Yi Jianbo Yang James B McCarthy Wei Xiong Minghua Wu Jian Ma Bo Su Zuping Zhang Qianjin Liao Bo Xiang Guiyuan Li

Promoter hypermethylation-mediated silencing of tumor suppressor genes (TSGs) is a hallmark of oncogenesis. Oxidored-nitro domain-containing protein 1 (NOR1) is a candidate TSG that is downregulated in nasopharyngeal carcinoma (NPC). In the present study, we identified a functional NOR1 promoter that is regulated by heat shock factor 1 and nuclear respiratory factor 1. The promoter is located w...

2016
DENG-QING LI MING QIU XIN-MIN NIE RONG GUI MIN-ZHU HUANG

Hepatocarcinogenesis is a stepwise process during which multiple genes are altered. Understanding the molecular mechanisms that induce hepatocarcinogenesis may improve the screening, prevention and treatment of patients with hepatocellular carcinoma (HCC). In recent years, the oxidored-nitro domain-containing protein 1 (NOR1) gene has been identified to have an important role in the development...

Journal: :Glycobiology 2007
Maria Duk Suddham Singh Vernon N Reinhold Hubert Krotkiewski Ewa Kurowska Elwira Lisowska

Rare polyagglutinable erythrocytes of NOR phenotype were found to contain two unique glycosphingolipids (designated NOR1 and NOR2). These components (not detected in normal erythrocytes) were reactive with Griffonia simplicifolia isolectin IB4 (GSL-IB4) and commonly present human anti-NOR antibodies. The NOR1 component has been reported to be a globoside containing a single galactose residue li...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید