To assess the role of combined immunomodulator and antibiotic therapy in sepsis, glucan--a beta 1,3 polyglucose--and gentamicin were administered in a model of murine peritonitis. ICR/HSD mice received one of four treatment regimens: 5% dextrose; gentamicin 0.02 mg intramuscularly (sub-MIC) 2 hours before peritonitis; glucan 0.1 mg intraperitoneally 24 hours before peritonitis; combined glucan-...

The burden of respiratory tract infections in paediatrics is extremely high, in both industrialised and developing countries. Because adequate diagnosis and causative therapies of these often recurrent respiratory tract infections bear substantial limits, preventive measures deserve priority. The mainstays are parent education, active immunisation strategies and nonspecific immunostimulation wi...

In this respect, fish are reliant on passive immunostimulation from maternal antibodies, and this mechanism has been shown in tilapias (Mor et al, 1990; Sin et al 1994). In any given species, size rather than age seems to be the most critical determinant of the development of immunity. For example, in salmonids, memory-dependent immunity has been achieved for sizes > 0.26g (8 weeks of age), whe...

The effects of specific dead tumor cell immunization and nonspecific immunostimulation with Corynebacterium parvum on the s.c. growth of the line 1 carcinoma in syngeneic BALB/c mice have been studied. Injection of heavily irradiated line ) carcinoma cells did not inhibit the transplantability or growth of the line 1 carcinoma, and in certain cases these treatments actually prolonged the period...

Interaction of microgram quantities of highly purified rabbit anti-TNP antibodies with TNP-substituted HeLa, HEp-2, and L cells caused an intense stimulation of radioactive nucleoside ([(125)I]UdR and [(3)H]TdR) uptake which was maximal 24-72 h after exposure of cells to antibody. The stimulation of nucleoside uptake and presumaly DNA synthesis was shown to be immuno logically mediated because ...