objective(s): haemostasis prevents blood loss following vascular injury. it depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. the clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. clotting insufficiency mostly occurs due to genetically inherited coagulation fact...

2 Background 5 Materials and Methods 10 Results 15 Discussion 26 Appendix 31 Bibliography 32 Acknowledgements 35

In testing the hypothesis that surface phonetic form is included in short-term memory (STM) representation, the tone sandhi phenomenon in Mandarin Chinese was exploited, and, as a prerequisite, the hypothesis that tonal similarity affects STM of verbal material in a tone language was also tested. In Experiment 1, subjects recalled visually presented sequences of seven monosyllabic Chinese morph...

Objective(s): Haemostasis prevents blood loss following vascular injury. It depends on the unique concert of events involving platelets and specific blood proteins, known as coagulation factors. The clotting system requires precise regulation and coordinated reactions to maintain the integrity of the vasculature. Clotting insufficiency mostly occurs due to genetically inherited coagulation fact...

Nobody's perfect, and even the cell turns out a certain fraction of erroneous mRNA transcripts. One of the key quality control mechanisms put in place to recognize and eliminate these transcripts before they can be translated into faulty proteins is nonsense-mediated decay. Proteins involved in nonsense-mediated decay are highly conserved across species from plants to humans, and recent studies...

enshrined in the global TREAT-NMD registries (http:// www.treat-nmd.eu/resources/patient-registries/overview) to which the Canadian registry is an active contributor. Ensuring that patients with rare diseases get access to the best quality diagnosis and care presents challenges that are best addressed by networking and sharing of resources. It is good to see this concept bear fruit in the paedi...

Translation and mRNA decay are coupled processes; the link is most obvious in the case of NMD (nonsense-mediated mRNA decay). NMD is a mechanism that drastically reduces the level of mRNA harbouring PTCs (premature translation termination codons). The defining event in NMD is premature translation termination and the key question is: what distinguishes premature from normal translation terminat...

Is it important? Absolutely! NMD probably evolved to eliminate abnormal transcripts due to routine errors in gene expression. For example, inefficient or inaccurate pre-mRNA splicing can generate an intron-derived in frame nonsense codon, or a shift in the reading frame and an exon-derived nonsense codon downstream of the shift. There are also natural substrates for NMD such as alternatively sp...