background & aim: we described the presentation, management and subsequent treatment outcomes of children and adolescents diagnosed with a pituitary adenoma in a joint neuroendocrine setting followed up by a single service as well as assessing long-term outcomes in terms of endocrine status and neurology symptoms. methods & materials/patients: a total of 21 participants with histologically veri...

Pituitary adenomas comprise 10% of intracranial tumors and occur in about 20% of the population. They cause significant morbidity by compression of regional structures or the inappropriate expression of pituitary hormones. Their molecular pathogenesis is unclear, and the current classification of clinically nonfunctional tumors does not reflect any molecular distinctions between the subtypes. T...

Pituitary adenomas comprise 10% of intracranial tumors and occur in about 20% of the population. They cause significant morbidity by compression of regional structures or the inappropriate expression of pituitary hormones. Their molecular pathogenesis is unclear, and the current classification of clinically nonfunctional tumors does not reflect any molecular distinctions between the subtypes. T...

Endoscopic endonasal transsphenoidal surgery (EETS) is a widely accepted technique for the surgical resection of pituitary tumours. In this report, we present our single-centre experience with EETS adenomas, mainly focusing on its efficacy and postoperative complications. Among 100 patients who underwent EETS, 57 (57%) were female 43 (43%) male. The mean age was 51.55 ± 13.51 years. Nonfunction...

AIM Human pituitary adenomas account for 10% of intracranial tumours and occur in about 20% of the population. They cause hypopituitarism or the compression of adjacent regional structures. However, little is known about the molecular pathogenesis that contributes to the development of these tumours. MATERIAL AND METHODS In this study, we investigated the relationship between the expression l...

The classification of pituitary tumors is frequently updated to optimize guidance for clinical treatment based on current knowledge. To date, the World Health Organization conducts periodic expert review consensus meetings and publishes results. These include recommendations behavior more aggressive, high Ki-67 index (>3%)pituitary. A Knosp grade (>3) associated with a risk recurrence. We repor...

BACKGROUND P53 expression and increased MIB-1 proliferation index have been shown to correlate with invasive behavior in pituitary adenomas. The purpose of this study was to determine whether these indices could be used to predict a higher likelihood of recurrence in clinically nonfunctional pituitary adenomas and thus guide adjuvant therapy. METHODS Fifty-one clinically nonfunctional pituita...

Silent corticotroph adenomas (SCAs) are immunopositive for adrenocorticotropic hormone (ACTH) but do not cause Cushing disease. They account approximately 20% of all and 5% nonfunctioning pituitary (NFAs). We present a case an SCA with extensive invasion outside the sella turcica causing pathology through mass effect on adjacent structures. A 48-year-old male was found to have 3.8 cm left caver...