gastroesophageal reflux (ger) is one of the most common causes of chronic cough, and chronic cough due to ger represents a subtype of ger-related diseases. gastroesophageal reflux-induced chronic cough (gerc) can be divided into two subgroups based on the ph of the ger. nonacid gerc is less common than acid gerc, and its diagnosis and treatment strategy have not been standardized.however, nonac...

BACKGROUND Combined multichannel intraluminal impedance and pH-metry (MII-pH) is a technique that enables monitoring of gastroesophageal reflux independent of its acidity. AIM To investigate the utility of MII-pH in the clinical investigation of patients with gastroesophageal reflux disease (GERD) symptoms. METHODS 32 consecutive patients underwent 24-hour ambulatory MII-pH. 16 patients wer...

Gastroesophageal reflux (GER) is one of the most common causes of chronic cough, and chronic cough due to GER represents a subtype of GER-related diseases. Gastroesophageal reflux-induced chronic cough (GERC) can be divided into two subgroups based on the pH of the GER. Nonacid GERC is less common than acid GERC, and its diagnosis and treatment strategy have not been standardized. However, nona...

Numerous studies have investigated utility of esophageal intraluminal baseline impedance levels (BILs) in gastroesophageal reflux disease (GERD). However, effect of BILs in refractory GERD (RGERD) has not been well investigated. The aim of this study is to evaluate role of BILs in RGERD patients. Total 62 subjects with refractory gastroesophageal reflux symptoms underwent 24-hour impedance-pH m...

(or the treatment of gastroesophageal reflux) and outcomes in IPF. Patients taking oral antiacid therapy appear to have a slower rate of decline in lung function [5] and improved survival [6] . In addition, there is evidence suggesting that gastroesophageal reflux may be an important cause of acute exacerbation [5, 7–8] . Both acid and nonacid reflux might play an important role, and in this re...

Gastroesophageal reflux (GER), asthma-type cough and upper airway disease are the most common causes of chronic cough syndrome. We present a case in which impedance-pH monitoring indicated severe mixed acid-nonacid esophageal reflux reaching the upper third of the esophagus in 75% of nonacid events. GER and the associated aspiration episodes were shown to be the cause of severe asthma attacks a...

Multichannel intraluminal impedance is a relatively new technology that allows detection of bolus movement in the gastrointestinal tract without the use of radiation. In clinical applications it is combined with manometry, allowing a better evaluation of the functional characteristics (ie, bolus transit) of esophageal motility abnormalities. When combined with pH monitoring, it provides more co...

BACKGROUND/AIMS Laryngopharyngeal symptoms of gastroesophageal reflux disease (GERD) such as globus sensation, hoarseness and chronic cough are becoming increasingly recognized. This study was aimed to investigate the diagnostic usefulness of combined dual channel multichannel intraluminal impedance (MII)/pH-metry in 'off-proton pump inhibitor (PPI)' patients with suspected laryngopharyngeal re...

CONTEXT Laryngopharyngeal reflux (LPR) is a major cause of laryngeal inflammation and presents with a constellation of symptoms different from classic gastroesophageal reflux disease. OBJECTIVE To provide a practical approach to evaluating and managing cases of LPR. EVIDENCE ACQUISITION The PubMed database and the Ovid Database of Systematic Reviews were systematically searched for laryngop...

To determine the relationship between baseline impedance levels and gastroesophageal reflux, we retrospectively enrolled 110 patients (54 men and 56 female; mean age, 51 ± 14 years) with suspected gastroesophageal reflux disease (GERD) who underwent 24-h multichannel intraluminal impedance and pH monitoring. Patients were stratified according to symptom (typical or atypical) and reflux types (a...