Fluorescence microscopy and the NO-sensitive indicator 4,5-diaminofluorescein were used to determine the effects of acetylcholine (ACh) on intracellular NO (NOi) in cat atrial myocytes. Field stimulation (1 Hz) of cells or exposure of quiescent cells to ACh (1 to 10 micromol/L) had no effect on NOi. However, in field-stimulated cells, ACh exposure increased NOi, and ACh withdrawal elicited an a...

INTRODUCTION New-onset insomnia (NOI) associated with nocturnal ventilatory support (NVS) is becoming a reality in clinical practice; however there is a lack of data about its prevalence. Our aim was to determine the prevalence of NOI in patients with obstructive sleep apnoea syndrome (OSAS) under NVS and its associated risk factors. MATERIAL AND METHODS Descriptive cross-sectional study of 8...

Un ultimo ringraziamento va a Lui, non si gioca a dadi qui, c'` e il Suo sogno per ognuno di noi, a noi non resta che viverlo.

La funzione di spaventare e allontanare gli uccelli da secoli riservata a figure mitologiche o fantocci costruiti in casa si è riversata negli ultimi decenni sugli umani, su quelle persone, nel giudizio comune ghettizzante, sul limitare dell’accettabilità. Gli spaventapasseri, che compaiono tra versi canzoni, albi per bambini scatti famosi, sono quel l’umano il burattino, testimoni delle umane ...

Generation of cell diversity in the vertebrate central nervous system starts during gastrulation stages in the ectodermal germ layer and involves specialized cell groups, such as the organizer located at the midbrain-hindbrain boundary (MHB). Mutations in the zebrafish no isthmus (noi) gene alter development of the MHB, and affect the pax2.1 gene (formerly pax(zf-b)). Analysis of the structure ...

Seasonal variation of plasma cholesterol levels was studied in 1446 hypercholesterolemic 35to 59-year-old male participants in the Lipid Research Clinics Coronary Primary Prevention Trial placebo group. Each man's serial cholesterol data, obtained at bimonthly intervals for 2.0 to 6.5 years, were analyzed as a separate periodic time series, and distributions of cycle zeniths and amplitudes were...

Această lucrare examinează literatura de specialitate cu privire la integrarea furnizorilor în realizarea de produse noi şi contribuie cu o cercetare empirică pentru a demonstra că diferenţierea tehnologică, performanţele afacerilor, inovarea şi comunicarea dintre companii şi furnizorii lor sunt pozitiv asociate cu nivelul de integrare al furnizorilor în realizarea de produse noi. În final, est...

Cyclodextrin-based host-guest chemistry has been exploited to facilitate co-crystallization of recombinant human acid β-glucosidase (β-glucocerebrosidase, GlcCerase) with amphiphilic bicyclic nojirimycin analogues of the sp(2)-iminosugar type. Attempts to co-crystallize GlcCerase with 5-N,6-O-[N'-(n-octyl)iminomethylidene]nojirimycin (NOI-NJ) or with 5-N,6-S-[N'-(n-octyl)iminomethylidene]-6-thi...

Rice (Oryza sativa L.) is the main food for people in Laos, where it has been grown and eaten since prehistory. Diverse landraces are grown in Laos. 'Khao Kai Noi', a landrace favored for its eating quality, is held in the nationwide collection of traditional landraces in the Lao national genebank. Genetic diversity is crucial for sustainable use of genetic resources and conservation. To invest...

A cohort of 2270 white women, aged 40-69 years at baseline, were followed for an average of 8.5 years in the Lipid Research Clinics Program Follow-up Study. There were 44 deaths due to cardiovascular disease among the 1677 nonusers of estrogens and six cardiovascular disease deaths among the 593 estrogen users. The age-adjusted relative risk (RR) of cardiovascular disease deaths in users compar...