نتایج جستجو برای: nmdar
تعداد نتایج: 2447 فیلتر نتایج به سال:
Background: We earlier reported that datumetine possesses binding affinity with NMDAR and that 14-day exposure to datumetine altered NMDAR signalling by mimicking glutamate toxicity. Here, we investigated the potential neuroprotective effect of a single shot of a low dose of datumetine administration in BALB/c mice. Results: Relative to Veh, datumetine downregulate the expression of CamKIIα i...
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a neuroinflammatory disease mediated by autoantibodies against the NMDAR, typically presenting with psychiatric symptoms, cognitive dysfunction, and motor dysfunction. These neuropsychiatric symptoms may be mimicked drug abuse, development of anti-NMDAR triggered certain substance use. Here we report case who developed after illicit use...
ObjectiveTo identify clinical variables that could predict the presence of autoantibodies in patients with acute encephalitis.MethodsAn observational, retrospective study from May 2011 to 2017. Clinical, EEG, brain MRI data, and antibodies against human neuronal antigens (NMDAR, GABAR, AMPAR, LGI1, CASPR2, GAD) 158 criteria for possible autoimmune encephalitis were analyzed create a predictive ...
Encapsulation of rat brain slices in agar gel solution for long-term and reversible cryopreservation
Earlier there was found activity of glutamatergic ionotropic α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPAR) and N-methyl-D-aspartate receptors (NMDAR) disturbed after prolonged cryopreservation brain slices at temperature -10 оС. To eliminate cryodamage AMPAR NMDAR, the were encapsulated in special freezing solution (SFS). SFS consisted agar various concentrations (33, 44 50 %) ar...
Es necesario el desarrollo de software educativo que permita la implementación prácticas laboratorio. En este trabajo se presenta diseño y del programa Lab-NMDAR, constituido por tres simuladores para enseñanza-aprendizaje electrofisiología receptor NMDA: (1) simulador NMDAR-Bloqueo Mg2+, (2) NMDAR-Glicina (3) canal único NMDA-Bloqueo Mg2+. El implementó en Visual Basic® ambiente Windows®. Con ...
Differences in the composition and subcellular localization of heteroreceptors brain can trigger central nervous system diseases, including epilepsy autism. Protein-protein interactions between Dopamine Receptors (DRs) GLUN2A GLUN2B subunits are critical mechanisms that regulate dopamine glutamate coordinated signals. These may be involved pathophysiological predisposition epilepsy. We hypothes...
anti-n-methyl-d-aspartate receptor (anti-nmdar) encephalitis is is most common form ofimmune-mediated encephalitis with prominent neurologic and psychiatric features at disease onset. we describe a 16 years old patient who presented with fever and status epilepticus. his mri sequences was normal. anti-nmdar antibodies were detected in the csf. mri, ct and other studies didn,t show any tumor.
Among aging-induced impairments, those affecting cognitive functions certainly represent one the most major challenge to face improve elderly quality of life. In last decades, our knowledge on changes in morphology and function neuronal networks associated with normal pathological brain aging has rapidly progressed, initiating development different pharmacological behavioural strategies allevia...
Underexpression of the transcriptional coactivator PGC-1 is causally linked to certain neurodegenerative disorders, including Huntington’s Disease (HD). HD pathoprogression is also associated with aberrant NMDAR activity, in particular an imbalance between synaptic versus extrasynaptic (NMDAR ) activity. Here we show that PGC-1 controls NMDAR EX activity in neurons and that its suppression cont...
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is is most common form ofimmune-mediated encephalitis with prominent neurologic and psychiatric features at disease onset. We describe a 16 years old patient who presented with fever and status epilepticus. His MRI sequences was normal. Anti-NMDAR antibodies were detected in the CSF. MRI, CT and other studies didn,t show any tum...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید