نتایج جستجو برای: nm23

تعداد نتایج: 572  

Journal: :The Journal of biological chemistry 1997
J M Freije P Blay N J MacDonald R E Manrow P S Steeg

We previously compared the structure and motility suppressive capacity of nm23-H1 by transfection of wild type and site-directed mutant forms into breast carcinoma cells. Wild type nm23-H1 and an nm23-H1(S44A) (serine 44 to alanine) mutant suppressed motility, whereas the nm23-H1(P96S), nm23-H1(S120G), and to a lesser extent, nm23-H1(S120A) mutant forms failed to do so. In the present study wil...

2011
Nozomi Niitsu Hirokazu Nakamine Masataka Okamoto

Purpose: We examined whether nm23-H1 is a prognostic factor of peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS). Experimental Design: We studied 102 consecutive, untreated PTCL-NOS patients from 1998 to 2008. The expression of nm23-H1 and TIA-1 was studied by immunohistochemistry. Results: nm23-H1 was positive in 44.1%, and TIA-1 in 78.4% of the PTCL-NOS patients. nm23-H1 expressi...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1997
P D Wagner P S Steeg N D Vu

Nm23 genes, which encode nucleoside diphosphate kinases, have been implicated in suppressing tumor metastasis. The motility of human breast carcinoma cells can be suppressed by transfection with wild-type nm23-H1, but not by transfections with two nm23-H1 mutants, nm23-H1(S12OG) and nm23-H1(P96S). Here we report that nm23-H1 can transfer a phosphate from its catalytic histidine to aspartate or ...

Journal: :Oncology reports 2007
Nan-Yung Hsu Chih-Yi Chen Chung-Ping Hsu Tze-Yi Lin Ming-Chih Chou Shiow-Her Chiou Kuan-Chih Chow

nm23-H1, a nucleoside diphosphate kinase (NDPK), enhances drug sensitivity and has antimetastatic activity, whereas focal adhesion kinase (FAK) is closely associated with cell migration and tumour spreading. The relationship between these two proteins, however, is not well elucidated. In this study, we investigate their correlation in patients with non-small cell lung cancer (NSCLC). Expression...

2009
Eunsun Lee Jaeho Jeong Sung Eun Kim Eun Joo Song Sang Won Kang Kong-Joo Lee

Nucleoside diphosphate kinase (NDPK, Nm23), a housekeeping enzyme, is known to be a multifunctional protein, acting as a metastasis suppressor, transactivation activity on c-myc, and regulating endocytosis. The cellular mechanisms regulating Nm23 functions are poorly understood. In this study, we identified the modifications and interacting proteins of Nm23-H1 in response to oxidative stress. W...

Journal: :Journal of the National Cancer Institute 2005
Mathieu Boissan Dominique Wendum Sandrine Arnaud-Dabernat Annie Munier Marcel Debray Ioan Lascu Jean-Yves Daniel Marie-Lise Lacombe

BACKGROUND The metastasis-suppressing role of the NM23 gene in the metastatic spread of solid tumors is still debated. We examined the role of NM23 in tumor development and metastatic dissemination by using transgenic mice that lack mouse NM23 (NM23-M1) in two mouse models of hepatocellular carcinoma (HCC) that recapitulate all steps of tumor progression. METHODS We induced HCC in mice that c...

Journal: :Cancer research 1995
N Iizuka M Oka T Noma A Nakazawa K Hirose T Suzuki

nm23 was originally identified as an antimetastatic gene, the expression of which was inversely correlated with tumor metastatic potential in rodent model systems. Subsequently, two related human nm23 genes, nm23-H1 and nm23-H2, were identified. The relationship between expression of nm23-H1 and nm23-H2 in hepatocellular carcinoma specimens from 30 patients and metastatic potential was investig...

Journal: :Cancer research 1993
L Wang U Patel L Ghosh H C Chen S Banerjee

The human nm23 gene, a candidate metastatic suppressor gene, consists of two genes, nm23-H1 and nm23-H2. The potential mutation in the nm23-H1 gene was examined in colorectal cancer using a reverse transcription polymerase chain reaction amplification followed by DNA sequencing analysis. Genomic alterations in the nm23 gene were also examined by Southern hybridization. Genetic alterations eithe...

Journal: :Clinical cancer research : an official journal of the American Association for Cancer Research 2004
Nozomi Niitsu Hirokazu Nakamine Masataka Okamoto Hiroko Akamatsu Masaaki Higashihara Yoshio Honma Junko Okabe-Kado Masami Hirano

PURPOSE Recently, we established an ELISA technique for measuring nm23-H1 protein in serum and found that the serum nm23-H1 level is a potential prognostic factor for patients with non-Hodgkin's lymphoma. EXPERIMENTAL DESIGN We used immunohistochemistry to examine the expression of nm23-H1 by the lymphoma cells in patients with diffuse large B-cell lymphoma (DLBCL). RESULTS By analyzing a c...

2016
Linlin Zhang Lin Li Huijun Wei Lili Guo Cheng Ai Hongyu Xu Zhihao Wu Qinghua Zhou

BACKGROUND Nm23-H1 was the first metastasis suppressor discovered in most tumor models and reduction or loss of nm23-H1 expression correlates with tumor progression and metastasis in non-small-cell lung cancer. Despite extensive studies, the regulatory mechanism of nm23-H1 expression is far from elucidated. The transcriptional factor forkhead box (FOX)O3 has been reported to be involved in mult...

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