نتایج جستجو برای: nlc

تعداد نتایج: 1175  

Probucol (PB) is a drug commonly used for the treatment of hyperlipidemia and atherosclerosis. In our previous study, we have proved that PB can ameliorate abdominal aortic aneurysm (AAA) induced by elastase in mice through its anti-inflammatory and anti-oxidative effect. In this study, the water solubility and oral absorption of PB were improved by encapsulating PB into nanostructured lipid ca...

The present study aimed to evaluate the effect of surfactant composition on the physical properties of nanostructured lipid carriers (NLCs) containing wheat germ oil (WGO) and to investigate the influence of both surfactant composition and pH on the oxidative stability of WGO encapsulated within the NLCs. The results showed that the smallest particle size (52.7 nm) was related to the NLC with t...

Journal: :Drug discoveries & therapeutics 2012
Pornthida Riangjanapatee Siriporn Okonogi

Nanostructured lipid carriers (NLC) have gained high interest as enhancing drug delivery systems via topical application during the last few years. NLC can enhance stability of many active substances against environmental stress. The extremely small size of NLC plays an important role in skin penetration. The unchanged size of NLC upon storage indicates its physical stability. The aim of this w...

Journal: :Optics express 2017
Domaniç Lavery Robert Maher Gabriele Liga Daniel Semrau Lidia Galdino Polina Bayvel

The Gaussian noise model is used to estimate the performance of three digital nonlinearity compensation (NLC) algorithms in C-band, long-haul, optical fiber transmission, when the span length and NLC bandwidth are independently varied. The algorithms are receiver-side digital backpropagation (DBP), transmitter-side DBP (digital precompensation), and Split NLC (an equal division of DBP between t...

2016
João P Barbosa Ana R Neves Andreia M Silva Mário A Barbosa M Salette Reis Susana G Santos

Dendritic cells (DCs) are promising targets for drug delivery, as they can induce immunity or tolerance. The current study aims to examine the potential of using nanostructured lipid carriers (NLC) as delivery systems for human DC by evaluating nanoparticle internalization, cell labeling, and drug activity. NLC were formulated incorporating the fluorochrome fluorescein isothiocyanate (FITC-NLC)...

2015
Wei Keat Ng Latifah Saiful Yazan Li Hua Yap Wan Abd Ghani Wan Nor Hafiza Chee Wun How Rasedee Abdullah

Thymoquinone (TQ) has been shown to exhibit antitumor properties. Thymoquinone-loaded nanostructured lipid carrier (TQ-NLC) was developed to improve the bioavailability and cytotoxicity of TQ. This study was conducted to determine the cytotoxic effects of TQ-NLC on breast cancer (MDA-MB-231 and MCF-7) and cervical cancer cell lines (HeLa and SiHa). TQ-NLC was prepared by applying the hot high p...

2015
Zhenyu Shao Jingyu Shao Bingxu Tan Shanghui Guan Zhulong Liu Zengjun Zhao Fangfang He Jian Zhao

PURPOSE Nanostructured lipid carriers (NLC) represent an improved generation of lipid nanoparticles. They have specific nanostructures to accommodate drugs/genes, and thus achieve higher loading capacity. The aim of this study was to develop transferrin (Tf)-decorated NLC as multifunctional nanomedicine for co-delivery of paclitaxel (PTX) and enhanced green fluorescence protein plasmid. METHO...

Journal: :Chemical & pharmaceutical bulletin 2008
Xinxin Zhang Weisan Pan Li Gan Chunliu Zhu Yong Gan Shufang Nie

Nanostructured lipid carriers (NLC) are based on mixture of solid lipids with spatially incompatible liquid lipids, which offer advantages of improving drug loading capacity and release properties. In the present study, hydroxycamptothecin (HCPT) loaded polyethylene glycol (PEG) modified NLC (PEG-NLC) was prepared by high pressure homogenize and spray drying method. PEG-NLC showed spherical par...

2014
Wenji Zhang Xuedong Li Tiantian Ye Fen Chen Shihui Yu Jianting Chen Xinggang Yang Na Yang Jinsong Zhang Jinlu Liu Weisan Pan Jun Kong

This study was carried out to evaluate the ocular performance of a cationic Eudragit (EDU) RS 100-coated nanostructured lipid carrier (NLC). The genistein encapsulated NLC (GEN-NLC) was produced using the melt-emulsification technique followed by surface absorption of EDU RS 100. The EDU RS 100 increased the surface zeta potential from -7.46 mV to +13.60 mV, by uniformly forming a spherical coa...

Journal: :Journal of Lightwave Technology 2021

The first-order (FO) perturbation theory-based nonlinearity compensation (PB-NLC) technique has been widely investigated to combat the detrimental effects of intra-channel Kerr in polarization-multiplexed (Pol-Mux) optical fiber communication systems. However, NLC performance FO-PB-NLC is significantly limited highly nonlinear regimes Pol-Mux long-haul transmission In this paper, we extend FO t...

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